韩国成年人中甘油三酯与高密度脂蛋白胆固醇比值与糖尿病发病率呈正相关。
Positive association between the ratio of triglycerides to high-density lipoprotein cholesterol and diabetes incidence in Korean adults.
机构信息
College of Nursing, Mo-Im Kim Nursing Research Institute, Yonsei University, 50-1, Yonsei-Ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Department of Information and Statistics, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju, Chungbuk, 28644, Republic of Korea.
出版信息
Cardiovasc Diabetol. 2021 Sep 9;20(1):183. doi: 10.1186/s12933-021-01377-5.
BACKGROUND
Insulin resistance is associated with the incidence of diabetes and cardiovascular diseases such as myocardial infarction. The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) (TG/HDL-C ratio) is positively correlated with insulin resistance. This study aimed to investigate the relationship between the TG/HDL-C ratio and the incidence of diabetes in Korean adults.
METHODS
This retrospective study used data from the National Health Insurance Service-National Health Screening Cohort. The TG/HDL-C ratio was divided into three tertiles, the T, T, and T groups, based on sex. We estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) for diabetes using multivariate Cox proportional hazards regression analyses.
RESULTS
A total of 80,693 subjects aged between 40 and 79 years were enrolled. The median follow-up period was 5.9 years. The estimated cumulative incidence of diabetes in the T, T, and T groups was 5.94%, 8.23%, and 13.50%, respectively, in men and 4.12%, 4.72%, and 6.85%, respectively, in women. Compared to T, the fully adjusted HRs (95% CIs) of the T and T groups for new-onset diabetes were 1.17 (1.06-1.30) and 1.47 (1.34-1.62), respectively, in men and 1.20 (1.02-1.42) and 1.52 (1.30-1.78), respectively, in women.
CONCLUSIONS
Increased TG/HDL-C ratio was significantly associated with a higher risk of new-onset diabetes in both sexes.
背景
胰岛素抵抗与糖尿病和心肌梗死等心血管疾病的发生有关。甘油三酯（TG）与高密度脂蛋白胆固醇（HDL-C）的比值（TG/HDL-C 比值）与胰岛素抵抗呈正相关。本研究旨在探讨韩国成年人 TG/HDL-C 比值与糖尿病发病的关系。
方法
本回顾性研究使用了国家健康保险服务-国家健康筛查队列的数据。根据性别，将 TG/HDL-C 比值分为三个三分位组，即 T、T 和 T 组。我们使用多变量 Cox 比例风险回归分析估计了糖尿病的风险比（HR）和 95%置信区间（CI）。
结果
共纳入 80693 名年龄在 40 至 79 岁之间的受试者。中位随访时间为 5.9 年。在男性中，T、T 和 T 组的糖尿病累积发生率分别为 5.94%、8.23%和 13.50%，在女性中分别为 4.12%、4.72%和 6.85%。与 T 相比，T 和 T 组新发糖尿病的调整后 HR（95%CI）分别为 1.17（1.06-1.30）和 1.47（1.34-1.62），在女性中分别为 1.20（1.02-1.42）和 1.52（1.30-1.78）。
结论
TG/HDL-C 比值升高与男性和女性新发糖尿病的风险增加显著相关。
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