Pedreño Raquel Meirelles, Matsumura Erika, Silva Liliane Aparecida Fagundes, Samelli Alessandra Giannella, Magliaro Fernanda Cristina Leite, Sanches Seisse Gabriela Gandolfi, Lobo Ivone Ferreira Neves, Lorenzi-Filho Geraldo, Carvallo Renata Mota Mamede, Matas Carla Gentile
Department of Physical Therapy, Speech-Language Pathology and Audiology, and Occupational Therapy, Faculty of Medicine (FMUSP), University of São Paulo, Rua Cipotânea, 51, São Paulo, CEP: 05360-160, Brazil.
Sleep Laboratory, Pulmonary Division, Instituto Do Coração, University of São Paulo, São Paulo, Brazil.
Sleep Breath. 2022 Mar;26(1):315-323. doi: 10.1007/s11325-021-02406-z. Epub 2021 Jun 5.
To evaluate the influence of obstructive sleep apnea (OSA) on the P300 response of auditory event-related potentials (ERPs) and to correlate the electrophysiological findings with OSA severity.
Patients with no OSA and mild, moderate, and severe OSA according to polysomnography (PSG) with normal hearing and no comorbidities were studied. Individuals with a body mass index (BMI) ≥ 40 kg/m, hypertension, diabetes, dyslipidemia, the use of chronic medications, and a risk of hearing loss were excluded. All patients underwent full PSG and auditory ERP measurement using the oddball paradigm with tone burst and speech stimuli. For P300 analysis (latencies and amplitudes), normal multiple linear regression models were adjusted with the groups (No OSA, Mild OSA, Moderate OSA, Severe OSA), age, BMI, and Epworth score as explanatory variables.
We studied 54 individuals (47 males) aged 35 ± 8 years with a BMI of 28.4 ± 4.3 kg/m. Patients were divided according to the apnea-hypopnea index (AHI) derived from PSG into no OSA (n = 14), mild (n = 16), moderate (n = 12), and severe OSA (n = 12) groups. Patients with severe OSA presented prolonged P300 latencies with tone burst stimuli compared to patients with no OSA and those with mild and moderate OSA.
Severe OSA is associated with impairment of the P300 response of auditory ERPs, suggesting a decrease in the processing speed of acoustic information that may be mediated by the level of somnolence.
评估阻塞性睡眠呼吸暂停（OSA）对听觉事件相关电位（ERP）中P300反应的影响，并将电生理结果与OSA严重程度相关联。
研究对象为根据多导睡眠图（PSG）诊断为无OSA以及轻度、中度和重度OSA的患者，这些患者听力正常且无合并症。排除体重指数（BMI）≥40 kg/m²、患有高血压、糖尿病、血脂异常、正在使用慢性药物以及有听力损失风险的个体。所有患者均接受了完整的PSG检查，并使用包含短纯音和言语刺激的oddball范式进行听觉ERP测量。对于P300分析（潜伏期和波幅），以组（无OSA、轻度OSA、中度OSA、重度OSA）、年龄、BMI和爱泼沃斯嗜睡量表评分作为解释变量，调整了正常多元线性回归模型。
我们研究了54名年龄在35±8岁、BMI为28.4±4.3 kg/m²的个体（47名男性）。根据PSG得出的呼吸暂停低通气指数（AHI）将患者分为无OSA组（n = 14）、轻度组（n = 16）、中度组（n = 12）和重度OSA组（n = 12）。与无OSA以及轻度和中度OSA的患者相比，重度OSA患者在短纯音刺激下P300潜伏期延长。
重度OSA与听觉ERP的P300反应受损有关，提示声学信息处理速度降低，这可能由嗜睡程度介导。
