Department of Biology, University of Virginia, Charlottesville, VA, 22903, USA.
Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA.
Dev Biol. 2021 Sep;477:205-218. doi: 10.1016/j.ydbio.2021.05.019. Epub 2021 Jun 3.
Thyroid hormone is a key regulator of post-embryonic vertebrate development. Skin is a biomedically important thyroid hormone target organ, but the cellular and molecular mechanisms underlying skin pathologies associated with thyroid dysfunction remain obscure. The transparent skin of zebrafish is an accessible model system for studying vertebrate skin development. During post-embryonic development of the zebrafish, scales emerge in the skin from a hexagonally patterned array of dermal papillae, like other vertebrate skin appendages such as feathers and hair follicles. We show here that thyroid hormone regulates the rate of post-embryonic dermal development through interaction with nuclear hormone receptors. This couples skin development with body growth to generate a well ordered array of correctly proportioned scales. This work extends our knowledge of thyroid hormone actions on skin by providing in-vivo evidence that thyroid hormone regulates multiple aspects of dermal development.
甲状腺激素是脊椎动物胚胎后期发育的关键调节因子。皮肤是医学上重要的甲状腺激素靶器官，但与甲状腺功能失调相关的皮肤病理的细胞和分子机制仍不清楚。斑马鱼的透明皮肤是研究脊椎动物皮肤发育的一种易于接近的模型系统。在斑马鱼胚胎后期发育过程中，鳞片从真皮乳头的六边形图案中出现，就像其他脊椎动物皮肤附属物如羽毛和毛囊一样。我们在这里表明，甲状腺激素通过与核激素受体的相互作用来调节胚胎后期真皮的发育速度。这将皮肤发育与身体生长联系起来，形成一个排列整齐、比例正确的鳞片阵列。这项工作通过提供体内证据表明甲状腺激素调节真皮发育的多个方面，扩展了我们对甲状腺激素对皮肤作用的认识。
