Using a two-wave longitudinal design, the current study examined the relationship between early perceived parental phubbing and subsequent problematic smartphone use. As loneliness is a sensitive indicator of interpersonal problems and fear of missing out is a strong predictor of Internet-related addiction, we examined these two variables as possible mediators in this relationship based on existing literature. A total of 1447 Chinese adolescents (572 males and 875 females, mean age = 16.15 years) completed questionnaires regarding perceived parental phubbing, loneliness, fear of missing out, and problematic smartphone use. The results indicated that: (a) early fathers' phubbing (fphubbing) and mothers' phubbing (mphubbing) predicted adolescents' subsequent problematic smartphone use; (b) loneliness mediated the relationship between early fphubbing/mphubbing and adolescents' subsequent problematic smartphone use; and (c) loneliness and fear of missing out sequentially mediated the relationship between early fphubbing/mphubbing and adolescents' subsequent problematic smartphone use. These results suggested that three types of interventions could be effectively used to decrease the risk of problematic smartphone use among adolescents, namely, reducing perceived parental phubbing, relieving loneliness, and decreasing fear of missing out.