Freeman Fiona E, Burdis Ross, Kelly Daniel J
Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; Department of Mechanical, Manufacturing, and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; Department of Mechanical, Manufacturing, and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland.
Trends Mol Med. 2021 Jul;27(7):700-711. doi: 10.1016/j.molmed.2021.05.001. Epub 2021 Jun 2.
Regenerating large bone defects remains a significant clinical challenge, motivating increased interest in additive manufacturing and 3D bioprinting to engineer superior bone graft substitutes. 3D bioprinting enables different biomaterials, cell types, and growth factors to be combined to develop patient-specific implants capable of directing functional bone regeneration. Current approaches to bioprinting such implants fall into one of two categories, each with their own advantages and limitations. First are those that can be 3D bioprinted and then directly implanted into the body and second those that require further in vitro culture after bioprinting to engineer more mature tissues prior to implantation. This review covers the key concepts, challenges, and applications of both strategies to regenerate damaged and diseased bone.
修复大的骨缺损仍然是一项重大的临床挑战，这激发了人们对增材制造和3D生物打印的更大兴趣，以设计出更优质的骨移植替代物。3D生物打印能够将不同的生物材料、细胞类型和生长因子结合起来，开发出能够引导功能性骨再生的个性化植入物。目前生物打印此类植入物的方法分为两类，每类都有其自身的优缺点。第一类是那些可以进行3D生物打印然后直接植入体内的方法，第二类是那些在生物打印后需要进一步体外培养以在植入前构建更成熟组织的方法。本综述涵盖了这两种修复受损和患病骨骼策略的关键概念、挑战及应用。
