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支具治疗早期婴儿型脊柱侧凸的疗效:一项为期5年的前瞻性队列研究表明,特发性脊柱侧凸的疗效优于继发性脊柱侧凸——2021年SOSORT奖得主。

Efficacy of bracing in early infantile scoliosis: a 5-year prospective cohort shows that idiopathic respond better than secondary-2021 SOSORT award winner.

作者信息

Negrini S, Donzelli S, Jurenaite G, Negrini F, Zaina F

机构信息

Department of Biomedical, Surgical and Dental Sciences, University "La Statale", Milan, Italy.

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

出版信息

Eur Spine J. 2021 Dec;30(12):3498-3508. doi: 10.1007/s00586-021-06889-y. Epub 2021 Jun 6.

Abstract

PURPOSE

In conservative early onset scoliosis treatment, interest in bracing is growing because repeated general anaesthesia (required by casting) has been questioned for possible brain damages. We aimed to check the results in the medium term of bracing, comparing idiopathic (IIS) to secondary (SIS) infantile scoliosis.

METHODS

We performed a retrospective study in a consecutive prospective cohort. Inclusion criteria were: discovery of scoliosis and bracing below age 3; exclusion criteria: previous spine surgery, less than three consultations. We considered the following results: full (< 20° Cobb) and partial (< 30°) success; hold-up (progression < 5° but curve > 29°); partial (progression > 5°) and full (fusion) failure; statistics: ANOVA for repeated measures; linear mixed effect model with Cobb angle (dependent), time and diagnosis (independent) variables.

RESULTS

We included 34 infants (16 IIS and 18 SIS) of age 1·10 ± 0·10 (years·months), 44 ± 17° curves, 27 ± 10° rib vertebral angle difference, average observation 5·05 ± 3·03 years. We found progressive improvement of IIS and stability of SIS patients. Six IIS (37.5%) and one SIS (6%) reached brace weaning before puberty with 13 ± 5° (improvement 61 ± 15%, p < 0.001), after 4·11 ± 3·07 years of treatment. Three patients were fused, one IIS (6%) and two SIS (11%). Two IIS patients also reached end-of-growth with 18° (start 40° at 1·03 years) and 20° (start 32° at 2·12 years), respectively.

CONCLUSION

Bracing shows promising results in the medium term for high-degree IIS, with very few hold-ups (19%) and failures (12%). Conversely, failures prevail for SIS (full 11%), even if the partial failure (39%) is still a time-buying strategy.

摘要

目的

在保守治疗早发性脊柱侧弯中,由于石膏固定(需要反复全身麻醉)可能对大脑造成损害,人们对支具治疗的兴趣日益增加。我们旨在检查支具治疗的中期结果,比较特发性(IIS)和继发性(SIS)婴儿型脊柱侧弯。

方法

我们在一个连续的前瞻性队列中进行了一项回顾性研究。纳入标准为:3岁以下发现脊柱侧弯并使用支具;排除标准:既往有脊柱手术史、就诊次数少于三次。我们考虑了以下结果:完全成功(Cobb角<20°)和部分成功(<30°);维持(进展<5°但曲线>29°);部分失败(进展>5°)和完全失败(融合);统计分析:重复测量方差分析;采用Cobb角(因变量)、时间和诊断(自变量)变量的线性混合效应模型。

结果

我们纳入了34例年龄为1.10±0.10(岁·月)的婴儿(16例IIS和18例SIS),侧弯角度为44±17°,肋骨-椎体角差为27±10°,平均观察时间为5.05±3.03年。我们发现IIS患者病情逐渐改善,SIS患者病情稳定。6例IIS(37.5%)和1例SIS(6%)在青春期前停止使用支具,治疗4.11±3.07年后,侧弯角度为13±5°(改善61±15%,p<0.001)。3例患者进行了融合手术,1例IIS(6%)和2例SIS(11%)。2例IIS患者分别在生长结束时侧弯角度达到18°(1.03岁时起始角度为40°)和20°(2.12岁时起始角度为32°)。

结论

支具治疗在中期对高度IIS显示出有希望的结果,极少出现病情维持(19%)和失败(12%)情况。相反地,SIS的失败情况较为普遍(完全失败11%),即使部分失败(39%)仍是一种争取时间的策略。

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