炎症小体引擎的结构与功能。
Structures and functions of the inflammasome engine.
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Mass.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Mass.
出版信息
J Allergy Clin Immunol. 2021 Jun;147(6):2021-2029. doi: 10.1016/j.jaci.2021.04.018.
Abstract
Inflammasomes are molecular machines that carry out inflammatory responses on challenges by pathogens and endogenous dangers. Dysregulation of inflammasome assembly and regulation is associated with numerous human diseases from autoimmunity to cancer. In recent years, significant advances have been made in understanding the mechanism of inflammasome signaling using structural approaches. Here, we review inflammasomes formed by the NLRP1, NLRP3, and NLRC4 sensors, which are well characterized structurally, and discuss the structural and functional diversity among them.
摘要
炎症小体是一种分子机器，能够对外源病原体和内源性危险的挑战产生炎症反应。炎症小体的组装和调节失调与许多人类疾病有关，从自身免疫到癌症。近年来，利用结构方法研究炎症小体信号转导机制取得了重大进展。在这里，我们综述了结构上得到很好表征的 NLRP1、NLRP3 和 NLRC4 传感器形成的炎症小体，并讨论了它们之间的结构和功能多样性。
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