Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia.
Breast Dis. 2021;40(S1):S103-S107. doi: 10.3233/BD-219015.
AGR2 expression is associated with luminal breast cancer. Overexpression of AGR2 is a predictor of poor prognosis. Several studies have found correlations between AGR2 in disseminated tumor cells (DTCs) in breast cancer patients.
This study aims to determine the correlation between anterior Gradient2 (AGR2) expression with the incidence of distant metastases in luminal breast cancer.
This study was an observational study using a cross-sectional method and was conducted at Wahidin Sudirohusodo Hospital and the network. ELISA methods examine AGR2 expression from blood serum of breast cancer patients. To compare the AGR2 expression in metastatic patients and the non-metastatic patient was tested with Mann Whitney test. The correlation of AGR2 expression and metastasis was tested with the Rank Spearman test.
The mean value of AGR2 antibody expression on ELISA in this study was 2.90 ± 1.82 ng/dl, and its cut-off point was 2.1 ng/dl. Based on this cut-off point value, 14 subjects (66.7%) had overexpression of AGR2 serum ELISA, and 7 subjects (33.3%) had not. The mean value AGR2 was significantly higher in metastatic than not metastatic, 3.77 versus 1.76 (p < 0.01). The Spearman rank test obtained a p-value for the 2 tail test of 0.003 (p < 0.05), which showed a significant correlation of both, while the correlation coefficient of 0.612 showed a strong positive correlation of AGR2 overexpression and metastasis.
AGR2 expression is correlated with metastasis in Luminal breast cancer.
AGR2 表达与腔乳腺癌相关。AGR2 过表达是预后不良的预测因子。几项研究发现了乳腺癌患者播散性肿瘤细胞 (DTC) 中 AGR2 之间的相关性。
本研究旨在确定前梯度 2 (AGR2) 表达与腔乳腺癌远处转移发生率之间的相关性。
本研究为观察性研究，采用横断面方法，在万隆苏迪罗胡索多医院及其网络进行。ELISA 方法检测乳腺癌患者血清中 AGR2 的表达。采用 Mann-Whitney 检验比较转移性患者和非转移性患者的 AGR2 表达。采用秩和 Spearman 检验检验 AGR2 表达与转移的相关性。
本研究 ELISA 检测 AGR2 抗体表达的平均值为 2.90 ± 1.82ng/dl，其截断值为 2.1ng/dl。基于该截断值，14 名受试者（66.7%）的血清 ELISA 中 AGR2 过表达，7 名受试者（33.3%）没有。转移性患者的 AGR2 平均值明显高于非转移性患者，分别为 3.77 与 1.76（p<0.01）。双侧 2 尾检验的 Spearman 秩检验得到 p 值为 0.003（p<0.05），表明两者之间存在显著相关性，而 0.612 的相关系数表明 AGR2 过表达与转移之间存在强烈的正相关。
AGR2 表达与腔乳腺癌的转移相关。
