Jian Chaohui, Xu Yiting, Shen Yun, Wang Yufei, Ma Xiaojing, Bao Yuqian
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, People's Republic of China.
Diabetes Metab Syndr Obes. 2021 May 28;14:2407-2414. doi: 10.2147/DMSO.S313202. eCollection 2021.
Neck circumference (NC) represents the subcutaneous fat deposition in the neck and is an effective indicator for evaluating metabolic disorders, such as metabolic syndrome, subclinical atherosclerosis, and non-alcoholic fatty liver disease. Microalbuminuria (MAU) is regarded as a potential sign of systemic endothelial dysfunction and microvascular abnormalities. The aim of this study was to elucidate the association of NC with urine albumin-to-creatinine ratio (UACR) and MAU.
A total of 1882 Shanghai community residents were enrolled (816 men and 1066 women), with age ranging from 40 to 80 years. Anthropometric parameters, including NC, and biochemical indices were measured. MAU was determined if 30 mg/g ≤ UACR < 300 mg/g. An elevated NC was defined as NC ≥ 38.5 cm for men and NC ≥ 34.5 cm for women.
Individuals with an elevated NC had significantly higher prevalence of MAU and UACR values than those with normal NC in both men and women (all < 0.05). The logistic regression analysis showed that there were significant and positive associations between elevated NC and the increasing risk of MAU after adjusting for lipid profile and glycemic indices ( = 0.007 for men and = 0.009 for women). After further adjusting for blood pressure, elevated NC caused an 69.3% additional risk of MAU in men ( = 0.037) and the positive correlation in women disappeared ( = 0.131).
There was an independent and positive association between elevated NC and the risk of MAU in men in the Chinese community population.
ChiCTR1900024011.
颈围（NC）代表颈部皮下脂肪沉积，是评估代谢紊乱的有效指标，如代谢综合征、亚临床动脉粥样硬化和非酒精性脂肪性肝病。微量白蛋白尿（MAU）被视为全身内皮功能障碍和微血管异常的潜在标志。本研究旨在阐明颈围与尿白蛋白肌酐比值（UACR）和微量白蛋白尿之间的关联。
共纳入1882名上海社区居民（816名男性和1066名女性），年龄在40至80岁之间。测量了包括颈围在内的人体测量参数和生化指标。当30mg/g≤UACR<300mg/g时确定为微量白蛋白尿。颈围升高定义为男性颈围≥38.5cm，女性颈围≥34.5cm。
颈围升高的个体中，男性和女性的微量白蛋白尿患病率和UACR值均显著高于颈围正常者（均P<0.05）。逻辑回归分析显示，在调整血脂和血糖指标后，颈围升高与微量白蛋白尿风险增加之间存在显著正相关（男性P = 0.007，女性P = 0.009）。进一步调整血压后，颈围升高使男性微量白蛋白尿风险增加69.3%（P = 0.037），女性的正相关消失（P = 0.131）。
在中国社区人群中，颈围升高与男性微量白蛋白尿风险之间存在独立正相关。
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