Jian Chaohui, Xu Yiting, Shen Yun, Wang Yufei, Ma Xiaojing, Bao Yuqian
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
Int J Endocrinol. 2021 Apr 19;2021:5570193. doi: 10.1155/2021/5570193. eCollection 2021.
Neck circumference (NC) is a simple anthropometric index for the assessment of upper body obesity. Thyroid hormones are closely related to obesity, body fat distribution indicators, and metabolic parameters. However, there are currently no reports on the association between NC and thyroid hormones in the Chinese population. This study aimed to explore the relationship between NC and thyroid hormones in men with normal thyroid function.
A total of 737 euthyroid men from Shanghai communities were enrolled. Anthropometric parameters, including NC and waist circumference (WC), were measured. Serum thyroid hormones were measured by electrochemical luminescence immunoassay.
NC, WC, and body mass index (BMI) were significantly positively correlated with serum free triiodothyronine (FT3) (all < 0.05). FT3 levels all presented significant upward trends with the increase in NC, WC, or BMI quartiles (all for trend < 0.05), whereas there were no significant correlations between the three obesity indices and free thyroxine or thyroid-stimulating hormone (both > 0.05). After adjustment for metabolic confounding factors such as age, blood pressure, blood glucose, lipid profiles, and CRP in multiple linear regression analysis, the correlation between FT3 and NC disappeared (standardized = -0.015, =0.705), and FT3 remained significantly associated with WC (standardized = 0.103, =0.012) and BMI (standardized = 0.082, =0.047).
In euthyroid men from Shanghai communities, there was no independent correlation between serum FT3 levels and NC. The trial was registered with ChiCTR1900024011.
颈围（NC）是评估上身肥胖的一个简单人体测量指标。甲状腺激素与肥胖、体脂分布指标及代谢参数密切相关。然而，目前尚无关于中国人群中颈围与甲状腺激素之间关联的报道。本研究旨在探讨甲状腺功能正常男性中颈围与甲状腺激素之间的关系。
共纳入来自上海社区的737名甲状腺功能正常的男性。测量了包括颈围和腰围（WC）在内的人体测量参数。采用电化学发光免疫分析法测定血清甲状腺激素。
颈围、腰围和体重指数（BMI）与血清游离三碘甲状腺原氨酸（FT3）均呈显著正相关（均P<0.05）。随着颈围、腰围或BMI四分位数的增加，FT3水平均呈现显著上升趋势（趋势P均<0.05），而这三个肥胖指标与游离甲状腺素或促甲状腺激素之间均无显著相关性（均P>0.05）。在多元线性回归分析中对年龄、血压、血糖、血脂谱和CRP等代谢混杂因素进行校正后，FT3与颈围之间的相关性消失（标准化β=-0.015，P=0.705），而FT3仍与腰围（标准化β=0.103，P=0.012）和BMI（标准化β=0.082，P=0.047）显著相关。
在来自上海社区的甲状腺功能正常男性中，血清FT3水平与颈围之间无独立相关性。该试验在ChiCTR1900024011注册。
