预防性促红细胞生成素对极早产儿的神经保护作用：一项Meta分析更新
Prophylactic Erythropoietin for Neuroprotection in Very Preterm Infants: A Meta-Analysis Update.
作者信息
Fischer Hendrik S, Reibel Nora J, Bührer Christoph, Dame Christof
机构信息
Department of Neonatology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
出版信息
Front Pediatr. 2021 May 20;9:657228. doi: 10.3389/fped.2021.657228. eCollection 2021.
Abstract
A meta-analysis update of randomized controlled trials investigating recombinant human erythropoietin suggests improved neurodevelopmental outcome in preterm infants. There was substantial heterogeneity, which could be ascribed to a single trial. Exclusion of this trial featuring a high risk of bias abolished heterogeneity and any effects of recombinant human erythropoietin treatment.
摘要
一项关于重组人促红细胞生成素的随机对照试验的荟萃分析更新表明，早产婴儿的神经发育结局有所改善。存在显著的异质性，这可能归因于一项单一试验。排除这项存在高偏倚风险的试验后，异质性以及重组人促红细胞生成素治疗的任何效应均消失。
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