• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

预防性促红细胞生成素对极早产儿的神经保护作用：一项Meta分析更新

Prophylactic Erythropoietin for Neuroprotection in Very Preterm Infants: A Meta-Analysis Update.

作者信息

Fischer Hendrik S, Reibel Nora J, Bührer Christoph, Dame Christof

机构信息

Department of Neonatology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

出版信息

Front Pediatr. 2021 May 20;9:657228. doi: 10.3389/fped.2021.657228. eCollection 2021.

DOI:10.3389/fped.2021.657228
PMID:34095027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8173165/
Abstract

A meta-analysis update of randomized controlled trials investigating recombinant human erythropoietin suggests improved neurodevelopmental outcome in preterm infants. There was substantial heterogeneity, which could be ascribed to a single trial. Exclusion of this trial featuring a high risk of bias abolished heterogeneity and any effects of recombinant human erythropoietin treatment.

摘要

一项关于重组人促红细胞生成素的随机对照试验的荟萃分析更新表明，早产婴儿的神经发育结局有所改善。存在显著的异质性，这可能归因于一项单一试验。排除这项存在高偏倚风险的试验后，异质性以及重组人促红细胞生成素治疗的任何效应均消失。

相似文献

1
Prophylactic Erythropoietin for Neuroprotection in Very Preterm Infants: A Meta-Analysis Update.预防性促红细胞生成素对极早产儿的神经保护作用：一项Meta分析更新
Front Pediatr. 2021 May 20;9:657228. doi: 10.3389/fped.2021.657228. eCollection 2021.
2
Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants: A Meta-analysis.预防性早期使用促红细胞生成素对早产儿的神经保护作用：一项荟萃分析。
Pediatrics. 2017 May;139(5). doi: 10.1542/peds.2016-4317. Epub 2017 Apr 7.
3
Effect of Early Prophylactic High-Dose Recombinant Human Erythropoietin in Very Preterm Infants on Neurodevelopmental Outcome at 2 Years: A Randomized Clinical Trial.早期预防性应用高剂量重组人红细胞生成素对极早产儿 2 年神经发育结局的影响：一项随机临床试验。
JAMA. 2016 May 17;315(19):2079-85. doi: 10.1001/jama.2016.5504.
4
An approach to using recombinant erythropoietin for neuroprotection in very preterm infants.一种在极早产儿中使用重组促红细胞生成素进行神经保护的方法。
Pediatrics. 2008 Aug;122(2):375-82. doi: 10.1542/peds.2007-2591.
5
Late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants.晚期促红细胞生成素预防早产和/或低出生体重儿红细胞输血
Cochrane Database Syst Rev. 2014 Apr 23(4):CD004868. doi: 10.1002/14651858.CD004868.pub4.
6
Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants.早期使用促红细胞生成素预防早产和/或低出生体重儿的红细胞输血。
Cochrane Database Syst Rev. 2012 Sep 12(9):CD004863. doi: 10.1002/14651858.CD004863.pub3.
7
Neuroprotection with erythropoietin in preterm and/or low birth weight infants.促红细胞生成素对早产和/或低出生体重婴儿的神经保护作用。
J Clin Neurosci. 2014 Aug;21(8):1283-7. doi: 10.1016/j.jocn.2013.10.040. Epub 2014 Feb 6.
8
Late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants.晚期促红细胞生成素预防早产和/或低出生体重儿红细胞输血
Cochrane Database Syst Rev. 2012 Sep 12(9):CD004868. doi: 10.1002/14651858.CD004868.pub3.
9
Tract-based spatial statistics to assess the neuroprotective effect of early erythropoietin on white matter development in preterm infants.基于束流的空间统计学评估早期促红细胞生成素对早产儿脑白质发育的神经保护作用。
Brain. 2015 Feb;138(Pt 2):388-97. doi: 10.1093/brain/awu363. Epub 2014 Dec 22.
10
Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age.早产儿早期给予高剂量促红细胞生成素与胎龄相当足月时脑 MRI 异常的相关性研究。
JAMA. 2014 Aug 27;312(8):817-24. doi: 10.1001/jama.2014.9645.

引用本文的文献

1
Darbepoetin, Red Cell Mass, and Neuroprotection in Preterm Infants: A Randomized Clinical Trial.促红细胞生成素、红细胞容量与早产儿神经保护：一项随机临床试验
JAMA Pediatr. 2025 May 12. doi: 10.1001/jamapediatrics.2025.0807.
2
Darbepoetin alpha has an anxiolytic and anti-neuroinflammatory effect in male rats.达贝泊汀α在雄性大鼠中有抗焦虑和抗炎神经的作用。
BMC Immunol. 2024 Nov 11;25(1):75. doi: 10.1186/s12865-024-00665-5.
3
Early High-Dose Erythropoietin and Cognitive Functions of School-Aged Children Born Very Preterm.早期高剂量促红细胞生成素与极早早产儿童学龄期认知功能的关系。

本文引用的文献

1
Transfusions and neurodevelopmental outcomes in extremely low gestation neonates enrolled in the PENUT Trial: a randomized clinical trial.纳入 PENUT 试验的极低胎龄新生儿输血与神经发育结局：一项随机临床试验。
Pediatr Res. 2021 Jul;90(1):109-116. doi: 10.1038/s41390-020-01273-w. Epub 2021 Jan 11.
2
Neurodevelopmental Outcomes at Age 5 Years After Prophylactic Early High-Dose Recombinant Human Erythropoietin for Neuroprotection in Very Preterm Infants.早期预防性应用高剂量重组人红细胞生成素对极早产儿神经保护作用的 5 年神经发育结局
JAMA. 2020 Dec 8;324(22):2324-2327. doi: 10.1001/jama.2020.19395.
3
Effect of High-Dose Erythropoietin on Blood Transfusions in Extremely Low Gestational Age Neonates: Post Hoc Analysis of a Randomized Clinical Trial.
JAMA Netw Open. 2024 Sep 3;7(9):e2430043. doi: 10.1001/jamanetworkopen.2024.30043.
4
Strategies for addressing the needs of children with or at risk of developmental disabilities in early childhood by 2030: a systematic umbrella review.到 2030 年满足有或有发育障碍风险的儿童需求的策略：系统的伞式综述。
BMC Med. 2024 Feb 2;22(1):51. doi: 10.1186/s12916-024-03265-7.
5
Neurodevelopmental outcomes of preterm infants.早产儿的神经发育结局
Clin Exp Pediatr. 2023 Jul;66(7):281-287. doi: 10.3345/cep.2022.00822. Epub 2022 Dec 30.
6
Effect of Early High-Dose Recombinant Human Erythropoietin on Behavior and Quality of Life in Children Aged 5 Years Born Very Preterm: Secondary Analysis of a Randomized Clinical Trial.早期高剂量重组人红细胞生成素对 5 岁极早产儿行为和生活质量的影响：一项随机临床试验的二次分析。
JAMA Netw Open. 2022 Dec 1;5(12):e2245499. doi: 10.1001/jamanetworkopen.2022.45499.
7
Safety and Short-term Outcomes of High-Dose Erythropoietin in Preterm Infants With Intraventricular Hemorrhage: The EpoRepair Randomized Clinical Trial.高剂量促红细胞生成素治疗早产儿脑室周围出血的安全性和短期结局：EpoRepair 随机临床试验。
JAMA Netw Open. 2022 Dec 1;5(12):e2244744. doi: 10.1001/jamanetworkopen.2022.44744.
8
Thresholds for blood transfusion in extremely preterm infants: A review of the latest evidence from two large clinical trials.极早产儿输血阈值：两项大型临床试验的最新证据综述
Front Pediatr. 2022 Sep 20;10:957585. doi: 10.3389/fped.2022.957585. eCollection 2022.
9
Recent research on the effect of common treatments given in the perinatal period on neurodevelopment in offspring.近期有关围生期常见治疗方法对后代神经发育影响的研究。
Zhongguo Dang Dai Er Ke Za Zhi. 2022 Mar 15;24(3):332-338. doi: 10.7499/j.issn.1008-8830.2111002.
大剂量促红细胞生成素对极低胎龄新生儿输血的影响：一项随机临床试验的事后分析。
JAMA Pediatr. 2020 Oct 1;174(10):933-943. doi: 10.1001/jamapediatrics.2020.2271.
4
Early erythropoiesis-stimulating agents in preterm or low birth weight infants.早产或低出生体重婴儿早期促红细胞生成素刺激剂
Cochrane Database Syst Rev. 2020 Feb 11;2(2):CD004863. doi: 10.1002/14651858.CD004863.pub6.
5
A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants.早产儿红细胞生成素神经保护的随机试验。
N Engl J Med. 2020 Jan 16;382(3):233-243. doi: 10.1056/NEJMoa1907423.
6
Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants: A Meta-analysis.预防性早期使用促红细胞生成素对早产儿的神经保护作用：一项荟萃分析。
Pediatrics. 2017 May;139(5). doi: 10.1542/peds.2016-4317. Epub 2017 Apr 7.
7
Randomized trial of early erythropoietin supplementation after preterm birth: Iron metabolism and outcome.早产后早期补充促红细胞生成素的随机试验：铁代谢与结局
Early Hum Dev. 2017 Jun;109:44-49. doi: 10.1016/j.earlhumdev.2017.04.001. Epub 2017 Apr 20.
8
Effect of Early Prophylactic High-Dose Recombinant Human Erythropoietin in Very Preterm Infants on Neurodevelopmental Outcome at 2 Years: A Randomized Clinical Trial.早期预防性应用高剂量重组人红细胞生成素对极早产儿 2 年神经发育结局的影响：一项随机临床试验。
JAMA. 2016 May 17;315(19):2079-85. doi: 10.1001/jama.2016.5504.
9
Recombinant human erythropoietin improves neurological outcomes in very preterm infants.重组人促红细胞生成素可改善极早产儿的神经学预后。
Ann Neurol. 2016 Jul;80(1):24-34. doi: 10.1002/ana.24677. Epub 2016 May 11.
10
Preschool Assessment of Preterm Infants Treated With Darbepoetin and Erythropoietin.用达贝泊汀和促红细胞生成素治疗的早产儿的学前评估
Pediatrics. 2016 Mar;137(3):e20153859. doi: 10.1542/peds.2015-3859. Epub 2016 Feb 15.