Wang Yan, Jia Yuhong, Li Molin, Jiao Sirui, Zhao Henan
Scientific Research Center, The Second Hospital of Dalian Medical University, Dalian, China.
Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Front Cardiovasc Med. 2021 May 19;8:665993. doi: 10.3389/fcvm.2021.665993. eCollection 2021.
Exercise training has been extensively studied in heart failure (HF) and psychological disorders, which has been shown to worsen each other. However, our understanding of how exercise simultaneously protect heart and brain of HF patients is still in its infancy. The purpose of this study was to take advantage of big data techniques to explore hotspots and frontiers of mechanisms that protect the heart and brain simultaneously through exercise training. We studied the scientific publications on related research between January 1, 2003 to December 31, 2020 from the WoS Core Collection. Research hotspots were assessed through open-source software, CiteSpace, Pajek, and VOSviewer. Big data analysis and visualization were carried out using R, Cytoscape and Origin. From 2003 to 2020, the study on HF, depression, and exercise simultaneously was the lowest of all research sequences (two-way ANOVAs, < 0.0001). Its linear regression coefficient was 0.7641. The result of hotspot analysis of related keyword-driven research showed that inflammation and stress (including oxidative stress) were the common mechanisms. Through the further analyses, we noted that inflammation, stress, oxidative stress, apoptosis, reactive oxygen species, cell death, and the mechanisms related to mitochondrial biogenesis/homeostasis, could be regarded as the primary mechanism targets to study the simultaneous intervention of exercise on the heart and brain of HF patients with depression. Our findings demonstrate the potential mechanism targets by which exercise interferes with both the heart and brain for HF patients with depression. We hope that they can boost the attention of other researchers and clinicians, and open up new avenues for designing more novel potential drugs to block heart-brain axis vicious circle.
运动训练在心力衰竭（HF）和心理障碍方面已得到广泛研究，结果显示这两者会相互恶化。然而，我们对于运动如何同时保护HF患者心脏和大脑的理解仍处于起步阶段。本研究旨在利用大数据技术探索通过运动训练同时保护心脏和大脑的机制热点及前沿。我们研究了2003年1月1日至2020年12月31日期间来自Web of Science核心合集的相关研究科学出版物。通过开源软件CiteSpace、Pajek和VOSviewer评估研究热点。使用R、Cytoscape和Origin进行大数据分析和可视化。2003年至2020年期间，关于HF、抑郁症和运动同时进行的研究是所有研究序列中最少的（双向方差分析，<0.0001）。其线性回归系数为0.7641。相关关键词驱动研究的热点分析结果表明，炎症和应激（包括氧化应激）是共同机制。通过进一步分析，我们注意到炎症、应激、氧化应激、细胞凋亡、活性氧、细胞死亡以及与线粒体生物发生/稳态相关的机制，可被视为研究运动对伴有抑郁症的HF患者心脏和大脑同时干预的主要机制靶点。我们的研究结果揭示了运动干预伴有抑郁症的HF患者心脏和大脑的潜在机制靶点。我们希望这些结果能够引起其他研究人员和临床医生的关注，并为设计更多新型潜在药物以阻断心脑轴恶性循环开辟新途径。
