2004 年至 2022 年白细胞介素-33 的知识图谱和研究趋势：文献计量分析。

BACKGROUND: IL-33 has been studied widely but its comprehensive and systematic bibliometric analysis is yet available. The present study is to summarize the research progress of IL-33 through bibliometric analysis. METHODS: The publications related to IL-33 were identified and selected from the Web of Science Core Collection (WoSCC) database on 7 December 2022. The downloaded data was analyzed with bibliometric package in R software. CiteSpace and VOSviewer were used to conduct IL-33 bibliometric and knowledge mapping analysis. RESULTS: From 1 January 2004 to 7 December 2022, 4711 articles on IL-33 research published in 1009 academic journals by 24652 authors in 483 institutions from 89 countries were identified. The number of articles had grown steadily over this period. The United States of America(USA) and China are the major contributors in the field of research while University of Tokyo and University of Glasgow are the most active institutions. The most prolific journal is Frontiers in Immunology, while the Journal of Immunity is the top 1 co-cited journal. Andrew N. J. Mckenzie published the most significant number of articles and Jochen Schmitz was co-cited most. The major fields of these publications are immunology, cell biology, and biochemistry & molecular biology. After analysis, the high-frequency keywords of IL-33 research related to molecular biology (sST2, IL-1), immunological effects (type 2 immunity, Th2 cells), and diseases (asthma, cancer, cardiovascular diseases). Among these, the involvement of IL-33 in the regulation of type 2 inflammation has strong research potential and is a current research hotspot. CONCLUSION: The present study quantifies and identifies the current research status and trends of IL-33 using bibliometric and knowledge mapping analysis. This study may offer the direction of IL-33-related research for scholars.

背景：IL-33 已被广泛研究，但目前尚缺乏对其进行全面系统的文献计量分析。本研究旨在通过文献计量分析总结 IL-33 的研究进展。

方法：于 2022 年 12 月 7 日从 Web of Science Core Collection (WoSCC) 数据库中确定并选择与 IL-33 相关的出版物。使用 R 软件中的文献计量包对下载的数据进行分析。使用 CiteSpace 和 VOSviewer 对 IL-33 进行文献计量和知识图谱分析。

结果：从 2004 年 1 月 1 日至 2022 年 12 月 7 日，共检索到 1009 种学术期刊上发表的关于 IL-33 研究的 4711 篇文章，作者来自 89 个国家的 483 个机构，作者 24652 人。在此期间，文章数量稳步增长。美国和中国是该领域的主要贡献者，而东京大学和格拉斯哥大学是最活跃的机构。发文量最多的期刊是 Frontiers in Immunology，而被引频次最高的期刊是 Journal of Immunity。发表文章数量最多的作者是 Andrew N. J. Mckenzie，被引频次最高的作者是 Jochen Schmitz。这些出版物的主要领域是免疫学、细胞生物学和生物化学与分子生物学。分析后发现，与 IL-33 相关的分子生物学（sST2、IL-1）、免疫效应（2 型免疫、Th2 细胞）和疾病（哮喘、癌症、心血管疾病）等研究的高频关键词。其中，IL-33 参与 2 型炎症的调节具有很强的研究潜力，是当前的研究热点。

结论：本研究通过文献计量和知识图谱分析，对 IL-33 的研究现状和趋势进行了量化和识别。本研究可为学者提供与 IL-33 相关的研究方向。