Neurology & Stroke Department, St. Adalbert Hospital, Gdansk, Poland.
Neurology & Stroke Department, J. Korczak Specialist Hospital, Slupsk, Poland.
Neurol Neurochir Pol. 2021;55(3):310-313. doi: 10.5603/PJNNS.a2021.0036. Epub 2021 Jun 7.
The pandemic state of COVID-19 has resulted in new neurological post-infection syndromes. Recently, several papers have reported ataxia-myoclonus syndrome following SARS-CoV-2 infection. The aim of this study was to present our two cases and compare them to previously reported cases.
We present two video-accompanied new cases with ataxia-myoclonus syndrome following SARS-CoV-2 infection and discuss the studies published so far.
Ataxia-myoclonus syndrome, isolated myoclonus, opsoclonus-myoclonus syndrome as post-COVID-19 syndrome following infection have been described in 16 patients (including our two cases). Patients have been treated with intravenous immunoglobulins and/or steroids except for 4 patients, which resulted in a significant improvement within 1-8 weeks.
The increasing number of patients with a similar symptomatology shows a significant relationship between COVID-19 infection and ataxia-myoclonus syndrome. The subacute onset of neurological symptoms after a resolved COVID-19 infection and prominent response to immunotherapy may suggest that the neurological manifestations are immune-mediated. Although recovery is highly possible, it may take several weeks/months, and clinicians should be aware of this diagnosis and the beneficial effects of immunological treatment administered as soon as possible.
COVID-19 的大流行状态导致了新的神经感染后综合征。最近，有几篇论文报道了 SARS-CoV-2 感染后出现的小脑性共济失调-肌阵挛综合征。本研究旨在报告我们的两例病例，并与以往报道的病例进行比较。
我们介绍了两例伴有小脑性共济失调-肌阵挛综合征的新病例，这些病例是由 SARS-CoV-2 感染引起的，并讨论了迄今为止发表的研究。
孤立性肌阵挛、眼阵挛-肌阵挛综合征和感染后 COVID-19 综合征后的小脑性共济失调-肌阵挛综合征已在 16 名患者（包括我们的两例病例）中描述。除 4 例患者外，患者均接受了静脉注射免疫球蛋白和/或类固醇治疗，这些患者在 1-8 周内有显著改善。
越来越多具有相似症状的患者表明 COVID-19 感染与小脑性共济失调-肌阵挛综合征之间存在显著关系。COVID-19 感染后亚急性发作的神经症状和对免疫疗法的显著反应可能表明神经表现是免疫介导的。尽管恢复的可能性很高，但可能需要数周/数月，临床医生应意识到这一诊断，并尽快进行免疫治疗，以获得有益的效果。
