与 COVID-19 相关的肌阵挛和共济失调综合征患者的脑灌注的时间变化。

Department of Neurology, Graduate School of Medicine, Chiba University, Japan.

Department of Rehabilitation, Division of Occupational Therapy, Chiba Prefectural University of Health Sciences, Japan.

Intern Med. 2022 Apr 1;61(7):1071-1076. doi: 10.2169/internalmedicine.9171-21. Epub 2022 Feb 1.

Myoclonus and ataxia, with or without opsoclonus, have recently been recognized as a central nervous system syndrome associated with coronavirus disease-2019 (COVID-19). A 52-year-old Japanese man developed myoclonus and ataxia 16 days after the onset of COVID-19. Brain single-photon emission computed tomography (SPECT) revealed hyperperfusion in the cerebellum and hypoperfusion in the cerebral cortices with frontal predominance during the acute stage, which improved over two months. This study indicates that brain perfusion SPECT can be effective in detecting functional alterations in COVID-19-related myoclonus and ataxia.

肌阵挛和小脑共济失调，伴有或不伴有眼球震颤，最近被认为是一种与 2019 年冠状病毒病（COVID-19）相关的中枢神经系统综合征。一名 52 岁的日本男性在 COVID-19 发病后 16 天出现肌阵挛和小脑共济失调。大脑单光子发射计算机断层扫描（SPECT）显示在急性期小脑呈高灌注，大脑皮质呈低灌注，以额叶为主，在两个月内逐渐改善。本研究表明，脑灌注 SPECT 可有效检测 COVID-19 相关肌阵挛和小脑共济失调的功能改变。