Salve Sushmita, Bahiram Yogita, Jadhav Amol, Rathod Rajeshwari, Tekade Rakesh Kumar
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Gandhinagar, Gujarat, India.
Crit Rev Anal Chem. 2023;53(1):46-68. doi: 10.1080/10408347.2021.1934651. Epub 2021 Jun 7.
Preparation of the biological samples is one of the most critical steps in sample analysis. In past decades, the liquid-liquid extraction technique has been used to extract the desired analytes from complex biological matrices. However, solid-phase extraction (SPE) gained popularity due to versatility, simplicity, selectivity, reproducibility, high sample recovery %, solvent economy, and time-saving nature. The superior extraction efficiency of SPE can be attributed to the development of advanced techniques, including the nanosorbents technology. The nanosorbent technology significantly simplified the sample preparation, improved the selectivity, diversified the application, and accelerated the sample analysis. This review critically expands on the to-date advancements reported in SPE with particular regards to the nanosorbent technology.
生物样品的制备是样品分析中最关键的步骤之一。在过去几十年中，液液萃取技术一直用于从复杂的生物基质中提取所需的分析物。然而，固相萃取（SPE）因其多功能性、简单性、选择性、可重复性、高样品回收率、溶剂经济性和省时性而受到欢迎。SPE卓越的萃取效率可归因于先进技术的发展，包括纳米吸附剂技术。纳米吸附剂技术显著简化了样品制备，提高了选择性，拓展了应用范围，并加速了样品分析。本综述批判性地阐述了迄今为止在SPE方面所报道的进展，特别是关于纳米吸附剂技术的进展。
