Department of Dermatology, University of Kansas Medical Center, Kansas City.
Cutis. 2021 Apr;107(4):221-222. doi: 10.12788/cutis.0221.
Patients who present with multiple keratoacanthomas (KAs) associated with prurigo nodularis often pose a treatment challenge. These lesions often require aggressive treatment, such as Mohs micrographic surgery, surgical excision, electrodesiccation and curettage, intralesional steroid injection, and long-term acitretin. 5-Fluorouracil (5-FU) cream 5% has been shown to be effective; however, topical options are limited when 5-FU fails. We have found success using a high-potency topical steroid under occlusion, resulting in resolution of KAs and prurigo nodules.
患有多发性角化棘皮瘤（KA）并伴有结节性痒疹的患者常常需要面临治疗挑战。这些病变通常需要积极治疗，如Mohs 显微外科手术、手术切除、电干燥和刮除、皮损内类固醇注射以及长期服用阿维 A。5%氟尿嘧啶（5-FU）乳膏已被证明有效；然而，当 5-FU 治疗失败时，外用药物选择有限。我们发现使用封闭状态下的强效外用类固醇取得了成功，导致角化棘皮瘤和结节性痒疹消退。
