Department of Colorectal Surgery, Singapore General Hospital, Singapore City, Singapore.
Programme in Health Services and Systems Research, Duke-NUS Medical School, Singapore City, Singapore.
Colorectal Dis. 2021 Sep;23(9):2348-2360. doi: 10.1111/codi.15768. Epub 2021 Jun 27.
As populations age and cancer management improves, long-term survivorship and quality-of-life (QOL) outcomes are becoming equally important as oncological results. Data from Asian populations are scarce. We aimed to evaluate the sexual health, gastrointestinal function and QOL amongst colorectal cancer survivors in a tertiary referral centre in Singapore.
Adults who had undergone elective curative surgery for non-metastatic colorectal cancer at least 2 years prior were included. Exclusion criteria were cognitive disease, serious postoperative complications or recurrent cancer. Participants were invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires EORTC-QLQ-C30 and QLQ-CR29. Using multiple bivariate analysis, r scores were used to examine relationship trends between QOL domains and survivor sociodemographic and disease-specific characteristics.
From February 2017 to July 2019, 400 responses were recorded. Median age and follow-up duration were 64 years (range 32-90) and 78 months (interquartile range 49-113) respectively. Patients who had Stage III cancer had better overall QOL scores compared to Stage I/II. Rectal (vs. colon) cancer negatively influenced sexual health and gastrointestinal function, but did not appear to affect overall QOL. Amongst our cohort, 57% (n = 129) of men and 43% (n = 75) of women were sexually active. Markers of socioeconomic status, including employment, education and housing type, were found to significantly impact perception of various aspects of QOL.
Knowledge of factors which influence well-being can identify individuals who may benefit from tailored management strategies. Regular patient-doctor contact may play a role in building and maintaining positive perspectives of cancer survivors. Normative data should be obtained from local populations to facilitate future comparative research.
随着人口老龄化和癌症管理水平的提高，长期生存和生活质量（QOL）的结果变得与肿瘤学结果同样重要。亚洲人群的数据较为匮乏。我们旨在评估新加坡一家三级转诊中心的结直肠癌幸存者的性健康、胃肠道功能和生活质量。
纳入至少 2 年前接受过非转移性结直肠癌择期根治性手术的成年人。排除标准为认知疾病、严重术后并发症或癌症复发。邀请参与者填写欧洲癌症研究与治疗组织生活质量问卷 EORTC-QLQ-C30 和 QLQ-CR29。使用多元线性回归分析，r 分数用于研究 QOL 各领域与幸存者社会人口统计学和疾病特异性特征之间的关系趋势。
2017 年 2 月至 2019 年 7 月，共记录了 400 份回复。中位年龄和随访时间分别为 64 岁（范围 32-90）和 78 个月（四分位间距 49-113）。III 期癌症患者的总体 QOL 评分优于 I/II 期患者。直肠癌（与结肠癌相比）对性功能和胃肠道功能有负面影响，但似乎不会影响总体 QOL。在我们的队列中，57%（n=129）的男性和 43%（n=75）的女性有性生活。社会经济地位的标志物，包括就业、教育和住房类型，被发现显著影响对 QOL 各个方面的感知。
了解影响幸福感的因素可以确定可能受益于个性化管理策略的个体。定期的医患接触可能在建立和维持癌症幸存者的积极观点方面发挥作用。应从当地人群中获得规范数据，以促进未来的比较研究。
