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直肠癌手术治疗后患者生活质量的前瞻性评估:一项为期12个月的队列观察

Prospective Evaluation of the Quality of Life of Patients after Surgical Treatment of Rectal Cancer: A 12-Month Cohort Observation.

作者信息

Tarkowska Magdalena, Głowacka-Mrotek Iwona, Skonieczny Bartosz, Jankowski Michał, Nowikiewicz Tomasz, Jarzemski Marcin, Zegarski Wojciech, Jarzemski Piotr

机构信息

Department of Urology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, Poland.

Department of Rehabilitation, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, Poland.

出版信息

J Clin Med. 2022 Oct 7;11(19):5912. doi: 10.3390/jcm11195912.

Abstract

This study constitutes a prospective, three-stage evaluation of quality of life among patients receiving surgical treatment for colorectal cancer depending on the type of surgery performed (open anterior resection, laparoscopic anterior resection, abdominoperineal resection, or Hartmann’s procedure). The study included 82 patients treated at the Surgical Oncology Outpatient Department of the Oncology Center in Bydgoszcz from June 2019 to August 2021. The study tools consisted of diagnostic surveys and analyses of medical records. The standardized study tools were the surveys EORTC QLQ-C30 and QLQ-CR29. In addition, a proprietary questionnaire was developed to collect demographic data. Quality of life was measured at three time-points: the day before the surgery and 6 and 12 months post-surgery. Statistically significant differences (p < 0.05) were observed in the domains of role functioning (III, p = 0.030), body image (II, p < 0.001; III, p < 0.001), sexual functioning (II, p = 0.037), buttocks/anal area/rectum pain (III, p = 0.031), and embarrassment (II, p = 0.022; III, p = 0.010). Statistically significant differences in the functional and symptom scale scores were also observed within each group at different stages of cancer treatment. As shown by our study, the quality of life of patients treated for colorectal cancer is determined not only by the operating technique but also by sociodemographic and clinical factors. The use of minimally invasive surgical techniques enables patients to return to their social roles more quickly and improves their self-assessment of body image.

摘要

本研究对接受结直肠癌手术治疗的患者的生活质量进行了前瞻性三阶段评估,评估依据所施行手术的类型(开放式前切除术、腹腔镜前切除术、腹会阴联合切除术或哈特曼手术)。该研究纳入了2019年6月至2021年8月在比得哥什肿瘤中心外科肿瘤门诊接受治疗的82例患者。研究工具包括诊断性调查和病历分析。标准化研究工具为欧洲癌症研究与治疗组织生活质量核心问卷(EORTC QLQ-C30)和结直肠癌特异性问卷(QLQ-CR29)。此外,还编制了一份专有问卷以收集人口统计学数据。在三个时间点对生活质量进行了测量:手术前一天以及手术后6个月和12个月。在角色功能领域(III,p = 0.030)、身体形象(II,p < 0.001;III,p < 0.001)、性功能(II,p = 0.037)、臀部/肛门区域/直肠疼痛(III,p = 0.031)和尴尬(II,p = 0.022;III,p =  0.010)方面观察到具有统计学意义的差异(p < 0.05)。在癌症治疗的不同阶段,每组内的功能和症状量表评分也观察到具有统计学意义的差异。正如我们的研究所表明的,接受结直肠癌治疗的患者的生活质量不仅取决于手术技术,还取决于社会人口统计学和临床因素。使用微创外科技术可使患者更快地恢复其社会角色,并改善他们对身体形象的自我评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eb2/9573224/32a25cad3406/jcm-11-05912-g001.jpg

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