Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Key Laboratory of Clinical Pharmacology of Antibiotics, National Heath Commission, Shanghai, China.
Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0045621. doi: 10.1128/AAC.00456-21.
The family was designated in 2017. To date, two alleles have been discovered that are carried by plasmids. Here, we identified a new quinolone resistance gene, , in the chromosome of Enterobacter mori clinical isolate 08-091 in China. conferred decreased susceptibility to fluoroquinolones, similar to and . To investigate the precise origin of , , and , 79 -bearing strains producing 30 variants were retrieved from the NCBI database. Phylogenetic analysis illustrated two major clusters, QnrE and QnrE, produced mainly by the and strains, respectively. Comparison of the genetic context of alleles demonstrated that and alleles presumably were captured by ISE and mobilized from the and strains to the and Escherichia coli strains, respectively. was proposed to be named , since it has spread to another genus. All the alleles were harbored by the Enterobacter species, except those captured by ISE and mobilized into other species of . is probably the source of to alleles, and is the reservoir of .
该家族于 2017 年被指定。迄今为止，已发现两种携带质粒的等位基因。在这里，我们在中国的肠杆菌属临床分离株 08-091 的染色体中鉴定出一种新的喹诺酮类耐药基因 。 赋予了对氟喹诺酮类药物的低敏感性，类似于 和 。为了调查 的精确起源，我们从 NCBI 数据库中检索了 79 个携带 基因的菌株，这些菌株产生了 30 种变体。系统发育分析表明存在两个主要簇，QnrE 和 QnrE，主要由 和 菌株产生。对 等位基因的遗传结构进行比较后发现， 和 等位基因可能是由 ISE 捕获并从 菌株和 菌株分别转移到 和 菌株上的。 建议将其命名为 ，因为它已经传播到另一个属。除了那些被 ISE 捕获并转移到其他 的菌株中外，所有的 等位基因都存在于肠杆菌属中。 可能是 到 等位基因的来源，而 是 的储库。
