Biochemistry Department, Emory University, Atlanta, Georgia, USA.
Biological Sciences Department, University of North Carolina at Charlotte, Charlotte, North Carolina, USA.
Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0061121. doi: 10.1128/AAC.00611-21.
Antibiotic collateral sensitivity, in which acquired resistance to one drug leads to decreased resistance to a different drug, occurs in Burkholderia multivorans. Here, we observed that treatment of extensively drug-resistant variants evolved from a cystic fibrosis (CF) sputum sample isolate with either meropenem or sulfamethoxazole-trimethoprim, depending on past resistance phenotypes, resulted in increased sensitivity to five different classes of antibiotics. We further identified mutations, including putative resistance-nodulation-division efflux pump regulators and uncharacterized pumps, that may be involved in this phenotype in B. multivorans.
抗药性的交叉敏感性，即对一种药物的获得性耐药会导致对另一种药物的耐药性降低，在伯克霍尔德菌属中存在。在这里，我们观察到，根据过去的耐药表型，用美罗培南或磺胺甲恶唑-甲氧苄啶治疗从囊性纤维化（CF）痰样本中分离出的广泛耐药变体，导致对五种不同类别的抗生素的敏感性增加。我们进一步鉴定了可能参与这种表型的突变，包括假定的耐药性-结节-分裂外排泵调节剂和未鉴定的泵。
