保护伯克霍尔德氏菌复合群和类鼻疽伯克霍尔德氏菌种中耐药-结节-分裂外排泵介导的抗生素耐药性。
Conservation of Resistance-Nodulation-Cell Division Efflux Pump-Mediated Antibiotic Resistance in Burkholderia cepacia Complex and Burkholderia pseudomallei Complex Species.
机构信息
The Pathogen and Microbiome Institute, Northern Arizona Universitygrid.261120.6, Flagstaff, Arizona, USA.
Global and Tropical Health Division, Menzies School of Health Researchgrid.271089.5, Charles Darwin University, Darwin, Northern Territory, Australia.
出版信息
Antimicrob Agents Chemother. 2021 Aug 17;65(9):e0092021. doi: 10.1128/AAC.00920-21.
Abstract
Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in . We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.
摘要
伯克霍尔德菌复合群（Bcc）和类鼻疽伯克霍尔德菌复合群（Bpc）包含的病原体通常具有多重耐药性。主要的内在和获得性多药耐药机制是由耐药性-结节性分裂（RND）家族的泵介导的外排。通过比较生物信息学和在许多情况下的功能研究，我们推断基于 RND 泵的耐药机制在 中是保守的。我们建议将这些发现作为采用统一的 RND 外排泵命名法的基础。
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