1Centre Muraz, Institut National de Santé Publique, Bobo-Dioulasso, Burkina Faso.
3Ecole de Santé Publique, Université Libre de Bruxelles, Brussels, Belgium.
Am J Trop Med Hyg. 2021 Jun 7;105(1):207-216. doi: 10.4269/ajtmh.20-1043.
Burkina Faso has high prevalence of anemia in pregnancy (hemoglobin < 11 g/dL), despite the implementation of the WHO recommended guidelines. This study aimed to test the effects of personalized support for pregnant women at home on the trend of anemia prevalence in pregnancy. A cluster randomized trial was conducted from January 2015 to August 2016 at Sindou health district in Burkina Faso. Data were collected from 617 women in their first or second trimester of pregnancy, including 440 and 177 women in the intervention and control groups, respectively. The intervention consisted of a monthly home-based visit to the pregnant woman, focusing on nutritional counseling and pregnancy management, alongside an improvement antenatal visit quality. Compared with the prevalence of anemia in pregnancy in the control group [64.0% (95% confidence interval [CI]: 52.1-74.4%)], that of the intervention group was significantly lower from the fifth home visit onward [36.8% (95% CI: 32.1-41.8%)] (P < 0.001). The adjusted difference-in-differences in anemia prevalence between the two groups was -19.8% (95% CI: -30.2% to -9.4%) for women who received more than four home visits (P < 0.001). The corresponding difference in hemoglobin levels was 0.644 g/dL (95% CI: 0.309-0.167; P < 0.001). Personalized support for pregnant women at home, combined with appropriate antenatal care, can significantly reduce anemia prevalence during pregnancy in rural Burkina Faso.
布基纳法索孕妇贫血患病率较高（血红蛋白<11g/dL），尽管实施了世界卫生组织推荐的指南。本研究旨在检验为孕妇提供家庭个性化支持对孕期贫血患病率趋势的影响。一项整群随机试验于 2015 年 1 月至 2016 年 8 月在布基纳法索 Sindou 卫生区进行。研究纳入了 617 名处于妊娠 1 或 2 个月的孕妇，其中干预组和对照组分别有 440 名和 177 名孕妇。干预措施包括每月对孕妇进行一次家访，重点是营养咨询和妊娠管理，并改善产前检查质量。与对照组孕妇妊娠贫血患病率[64.0%（95%置信区间[CI]：52.1-74.4%）]相比，从第五次家访开始，干预组孕妇妊娠贫血患病率显著下降[36.8%（95% CI：32.1-41.8%）]（P<0.001）。两组间贫血患病率的调整差异-差异为接受超过四次家访的女性为-19.8%（95% CI：-30.2%至-9.4%）（P<0.001）。血红蛋白水平的相应差异为 0.644g/dL（95% CI：0.309-0.167；P<0.001）。为孕妇提供家庭个性化支持，结合适当的产前保健，可显著降低布基纳法索农村地区孕妇妊娠贫血的患病率。
