Department of Physics and Material Science, Madan Mohan Malaviya University of Technology, Gorakhpur, India.
Department of Chemistry and Environmental Science, Madan Mohan Malaviya University of Technology, Gorakhpur, India.
Photochem Photobiol. 2021 Nov;97(6):1498-1506. doi: 10.1111/php.13460. Epub 2021 Jun 21.
An efficient photocatalytic regeneration of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) has been carried out by two-electron reduction and protonation of NAD /NADP , induced by photons in the visible light region. This functional artificial photosynthetic counterpart of the complete energy-trapping occurring in natural photosystem I (PS I) is achieved with nitrogen-enrich graphene quantum dot (N-EGQD) as the light-harvesting photocatalyst. In buffer aqueous solution, this compound photo catalytically recycles a rhodium hydride complex of the type [CpRh(bpy)H] (Cp = pentamethylcyclopentadienyl, bpy = 2,2'-bipyridine) which can mediate hydride transfer processes leading to nucleotide co-factor reduction. Very promising yields of 73.31%/78.45% of NADH/NADPH with the excellent thermal stability of N-EGQD photocatalyst is observed. Thus, in this work, an efficient light-harvesting photocatalyst is synthesized for the regeneration of nicotinamide cofactor that has pharmaceuticals application.
通过可见光区域的光子诱导，NAD+/NADP 的两电子还原和质子化实现了烟酰胺腺嘌呤二核苷酸（NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的高效光催化再生。这种与天然光系统 I（PS I）中完全能量捕获功能对应的人工光合作用模拟物，是用富氮石墨烯量子点（N-EGQD）作为光收集光催化剂来实现的。在缓冲水溶液中，该化合物光催化循环[CpRh（bpy）H]（Cp= 五甲基环戊二烯基，bpy= 2,2'-联吡啶）的铑氢化物配合物，该配合物可以介导导致核苷酸辅助因子还原的氢转移过程。观察到具有优异热稳定性的 N-EGQD 光催化剂的 NADH/NADPH 的非常有前景的产率为 73.31%/78.45%。因此，在这项工作中，合成了一种用于烟酰胺辅因子再生的高效光收集光催化剂，该催化剂具有药物应用。
