Schnitzerling H J
CSIRO, Division of Tropical Animal Science, Queensland, Australia.
Exp Appl Acarol. 1988 Mar;4(2):141-9. doi: 10.1007/BF01193871.
With continuous and ultimately lethal exposure of eggs of Boophilus microplus to mercury vapour, respiration and non-protein thiol decreased to low levels. With sub-lethal exposure, respiration decreased initially and then increased, whereas non-protein thiol (largely glutathione) increased initially and then decreased. This initial increase in glutathione (GSH) which probably resulted from an attempt by the organism to control or reverse the biochemical lesion, did not arise from the oxidized form (GSSG) through a shift in the equilibrium from right to left thus: 2GSH in equilibrium GSSG + 2H+ + 2e-. The significance of the results are discussed in relation to theories of GSH function and of Hg toxicity. The possible application of mercurials in tick control is discussed.
随着微小牛蜱卵持续暴露于汞蒸气并最终达到致死剂量，其呼吸作用和非蛋白硫醇含量降至低水平。在亚致死剂量暴露下，呼吸作用起初下降，随后上升，而非蛋白硫醇（主要为谷胱甘肽）则先增加后减少。谷胱甘肽（GSH）的这种初始增加可能是生物体试图控制或逆转生化损伤的结果，并非源于氧化形式（GSSG）通过如下平衡从右向左的移动：2GSH⇌GSSG + 2H⁺ + 2e⁻。结合谷胱甘肽功能理论和汞毒性理论对结果的意义进行了讨论。还讨论了汞制剂在蜱虫控制中的可能应用。
