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一位患有多种肿瘤和囊性肺病的 44 岁女性。

A 44-Year-Old Woman With Multiple Neoplasms and Cystic Lung Disease.

机构信息

Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL.

Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL.

出版信息

Chest. 2021 Jun;159(6):e381-e384. doi: 10.1016/j.chest.2021.01.005.

DOI:10.1016/j.chest.2021.01.005
PMID:34099154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8213961/
Abstract

A 44-year-old woman with a history of renal cell carcinoma and thyroid cancer was referred to our institution for evaluation of cystic lung disease. She was an active smoker with a 15-pack-year of tobacco use. Two years before her presentation, she underwent a left nephrectomy for renal cell carcinoma, clear cell type. Four months before, she had a total thyroidectomy that showed nodules consistent with noninvasive follicular thyroid neoplasm with papillary like nuclear features. She had no previous pulmonary complaints. Her family history was positive for breast cancer in her grandmother. There was no family history of pneumothorax. She complained of mild shortness of breath with exertion and occasional nonproductive cough. As part of her oncologic work up, she underwent a chest CT scan of the lungs (Fig 1).

摘要

一位 44 岁的女性,既往有肾细胞癌和甲状腺癌病史,因囊性肺病到我院就诊。她是一名活跃的吸烟者,吸烟 15 包/年。在就诊前两年,她因左肾透明细胞癌行左肾切除术。四个月前,她行甲状腺全切术,术后病理提示非侵袭性滤泡性甲状腺肿瘤伴乳头状核特征的结节。她既往无肺部不适。其祖母有乳腺癌家族史。无气胸家族史。她诉活动后轻度呼吸困难,偶有干咳,无痰。作为肿瘤学检查的一部分,她进行了胸部 CT 扫描(图 1)。

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本文引用的文献

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Am J Clin Dermatol. 2018 Feb;19(1):87-101. doi: 10.1007/s40257-017-0307-8.
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Birt-Hogg-Dubé Syndrome.Birt-Hogg-Dubé 综合征。
Clin Chest Med. 2016 Sep;37(3):475-86. doi: 10.1016/j.ccm.2016.04.010. Epub 2016 Jun 25.
3
Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome.Birt-Hogg-Dubé综合征的分子遗传学与临床特征
Nat Rev Urol. 2015 Oct;12(10):558-69. doi: 10.1038/nrurol.2015.206. Epub 2015 Sep 1.
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Birt-Hogg-Dubé syndrome. State-of-the-art review with emphasis on pulmonary involvement.Birt-Hogg-Dubé综合征。重点关注肺部受累情况的最新综述。
Respir Med. 2015 Mar;109(3):289-96. doi: 10.1016/j.rmed.2014.11.008. Epub 2014 Dec 9.
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Characterization of pulmonary cysts in Birt-Hogg-Dubé syndrome: histopathological and morphometric analysis of 229 pulmonary cysts from 50 unrelated patients.Birt-Hogg-Dubé综合征中肺囊肿的特征:对50例无亲缘关系患者的229个肺囊肿进行组织病理学和形态计量学分析
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Pulmonary manifestations of Birt-Hogg-Dubé syndrome.Birt-Hogg-Dubé 综合征的肺部表现。
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Birt-Hogg-Dubé syndrome: diagnosis and management.Birt-Hogg-Dubé 综合征:诊断与管理。
Lancet Oncol. 2009 Dec;10(12):1199-206. doi: 10.1016/S1470-2045(09)70188-3.