Internal Medicine, Dr Rajinder Prasad Government Medical College, Kangra, Himachal Pradesh, India.
Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
BMJ Case Rep. 2021 Jun 7;14(6):e239239. doi: 10.1136/bcr-2020-239239.
Sarcoidosis is an autoimmune multisystem granulomatous disorder of unknown aetiology, which mainly affects the adults in the age group of 20-39 years. The disease can affect any organ in the body but mainly presents as bilateral hilar lymphadenopathy, pulmonary infiltrates, cutaneous lesions, ocular manifestations and arthropathy. Lofgren's syndrome is an uncommon initial presentation of sarcoidosis which is recognised by the classical triad of acute arthritis, erythema nodosum and bilateral hilar lymphadenopathy. We describe a newly diagnosed case of sarcoidosis who presented as Lofgren's syndrome. Acute sarcoid arthritis should be kept as one of the differential diagnoses for patients presenting with acute arthritis and skin lesions; and chest X-ray should be considered to rule out bilateral hilar lymphadenopathy in these patients. Early suspicion and identification of classical clinical features are essential to establish early diagnosis.
结节病是一种病因不明的自身免疫性多系统肉芽肿性疾病，主要影响 20-39 岁年龄段的成年人。该病可影响身体的任何器官，但主要表现为双侧肺门淋巴结肿大、肺部浸润、皮肤损伤、眼部表现和关节病。洛弗根综合征是结节病的一种不常见的初始表现，其特征为典型三联征，即急性关节炎、结节性红斑和双侧肺门淋巴结肿大。我们描述了一例新诊断的结节病患者，其表现为洛弗根综合征。对于出现急性关节炎和皮肤损伤的患者，应将急性结节病性关节炎作为鉴别诊断之一；对于这些患者，应考虑胸部 X 光检查以排除双侧肺门淋巴结肿大。早期怀疑和识别典型的临床特征对于早期诊断至关重要。
