Sejdic A, Graudal N, Baslund B
a Copenhagen Lupus and Vasculitis Clinic, Centre for Rheumatology and Spine Diseases , Rigshospitalet and University of Copenhagen , Copenhagen , Denmark.
Scand J Rheumatol. 2018 Nov;47(6):487-490. doi: 10.1080/03009742.2017.1420818. Epub 2018 Jun 22.
The presentation of sarcoidosis can involve symptoms from all organs and the diagnosis is therefore often difficult. A raised serum level of serum angiotensin-converting enzyme (sACE) can be detected in 41-58% of patients. However, whether the sACE level per se reflects the severity of the sarcoid inflammation at the onset of the disease is not well described. The purpose of this study was to investigate the clinical and laboratory significance of high versus normal sACE levels in sarcoidosis.
Journal data were retrospectively extracted from 101 patients from our clinic. Clinical and biochemical data were compared between patients with high sACE levels (> 115 U/L) on at least one occasion and normal sACE levels (< 115 U/L).
In total, 48% (n = 48) of the patients had high ACE and 52% (n = 53) had normal ACE. The most common extrapulmonary manifestation for both groups was arthritis, followed by skin and eye involvement, but none of these differed between the two groups. Serum ionized calcium was significantly higher in the high sACE group, with a correlation coefficient of 0.112 (p = 0.460).
Our study demonstrates that serum ionized calcium is significantly higher in the high sACE group but there was no statistical correlation to sACE. No other clinical or biochemical differences were observed.
结节病的表现可累及所有器官的症状，因此诊断往往困难。41% - 58%的患者血清血管紧张素转换酶（sACE）水平会升高。然而，sACE水平本身是否反映疾病发作时结节病炎症的严重程度，目前尚无充分描述。本研究的目的是调查结节病中sACE水平高与正常的临床和实验室意义。
回顾性提取我们诊所101例患者的病历数据。比较至少有一次sACE水平高（> 115 U/L）的患者和sACE水平正常（< 115 U/L）的患者的临床和生化数据。
总共有48%（n = 48）的患者ACE水平高，52%（n = 53）的患者ACE水平正常。两组最常见的肺外表现都是关节炎，其次是皮肤和眼部受累，但两组之间这些表现并无差异。高sACE组的血清离子钙显著更高，相关系数为0.112（p = 0.460）。
我们的研究表明，高sACE组的血清离子钙显著更高，但与sACE无统计学相关性。未观察到其他临床或生化差异。
