Rachkov A K
Farmakol Toksikol. 1988 May-Jun;51(3):41-5.
In experiments on rats it was shown that administration of succinic and nicotinic acids in doses of 30 and 4 mg/kg for 5 days elevated pyruvic acid level and changed catecholamine balance in tissues of the aorta and heart. The administration of the drugs to rats with current-induced stress partially eliminated unfavourable shifts in carbohydrate metabolism and catecholamine balance in the aortic and cardiac tissues. Succinic acid had more pronounced metabolic activity.
在大鼠实验中表明，以30毫克/千克和4毫克/千克的剂量分别给予琥珀酸和烟酸5天，可提高丙酮酸水平，并改变主动脉和心脏组织中的儿茶酚胺平衡。给遭受电流诱导应激的大鼠服用这些药物，可部分消除主动脉和心脏组织中碳水化合物代谢和儿茶酚胺平衡的不利变化。琥珀酸具有更显著的代谢活性。
