Nikulin A A, Khrapova S I, Tebiakina E A, Rachkov A K, Semenchenko M V
Farmakol Toksikol. 1988 May-Jun;51(3):45-8.
A single administration of succinic acid was shown to cause a dose-dependent decrease of the blood coagulability in rats. Seven-day administration of succinic acid (50 mg/kg) resulted in a distinct increase of the blood coagulability, an accumulation of adrenaline in the heart and adrenal gland tissues. Hypercoagulation was noted on the 5th day after withdrawal of succinic acid (50 and 200 mg/kg).
单次给予琥珀酸可导致大鼠血液凝固性呈剂量依赖性降低。连续7天给予琥珀酸（50毫克/千克）会导致血液凝固性显著增加，肾上腺素在心脏和肾上腺组织中蓄积。在停用琥珀酸（50和200毫克/千克）后的第5天观察到高凝状态。
