Mutuskina E A, Zarzhetskiĭ Iu V, Trubina I E, Avrushchenko M Sh, Volkov A V, Pylova S I, Tsnobiladze M V, Lazareva N A, Stepanichev M Iu, Onufriev M V, Guliaeva N V, Gurvich A M
Anesteziol Reanimatol. 1996 Sep-Oct(5):61-3.
The effect of oral succinic acid was studied in rats exposed to 10-min heart arrest followed by resuscitation. The drug was administered for 5 days in a dose of 30 mg/kg starting from day 3 up to day 7 after resuscitation. Succinic acid was found to normalize the orientation and exploration behavior of rats in the "open field" test, decreased the intensity of response to stress (electric shock), and normalized the radical formation in the brain tissue and blood serum, thus reducing the morphological changes in the brain. In addition, succinic acid prevented the development of risk factors of atherogenesis, namely, increase of the levels of blood cholesterol, triglycerides, and low and very low density lipoproteins. Further studies are needed to validate the addition of succinic acid to the armory of drugs preventing the development of postresuscitation encephalopathies in remote (3 months) periods.
研究了口服琥珀酸对经历10分钟心脏骤停后复苏的大鼠的影响。从复苏后第3天至第7天，以30mg/kg的剂量给药该药物，持续5天。在“旷场”试验中，发现琥珀酸可使大鼠的定向和探索行为正常化，降低对应激（电击）的反应强度，并使脑组织和血清中的自由基形成正常化，从而减少大脑中的形态学变化。此外，琥珀酸可预防动脉粥样硬化危险因素的发展，即血液胆固醇、甘油三酯以及低密度和极低密度脂蛋白水平的升高。需要进一步研究以验证在预防远期（3个月）复苏后脑病发展的药物库中添加琥珀酸的作用。
