Stepaniuk G I, Lutsiuk N B, Piskun R P, Smirnova O V, Cherviak M N
Farmakol Toksikol. 1988 May-Jun;51(3):56-7.
Treatment of the adjuvant disease in rats by intragastric administration of voltaren or indomethacin (3 mg/kg) was followed by approximately equal anti-inflammatory and analgesic effects on the affected joints. In this case the development of active dystrophic changes in the gastrointestinal tract and kidneys was observed. At combined administration of the antiphlogistics with trental there was noted an enhancement of their therapeutic action on the joints and also a weakening of the ulcerogenic effect and nephrotoxicity that was reflected in the clinical, pathological, morphological and laboratory studies.
通过胃内给予扶他林或消炎痛（3毫克/千克）治疗大鼠佐剂性疾病后，对受影响关节产生了大致相同的抗炎和镇痛作用。在这种情况下，观察到胃肠道和肾脏出现了活动性营养不良性变化。当将这些抗炎药与曲克芦丁联合使用时，在临床、病理、形态学和实验室研究中发现，它们对关节的治疗作用增强，同时致溃疡作用和肾毒性减弱。
