Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Department of Immunology, Harvard Medical School, Boston, MA, USA.
Immunol Rev. 2021 Jul;302(1):86-103. doi: 10.1111/imr.12989. Epub 2021 Jun 8.
Fibroblasts and macrophages are universal cell types across all mammalian tissues. These cells differ in many ways including their cellular origins; dynamics of renewal, recruitment, and motility within tissues; roles in tissue structure and secretion of signaling molecules; and contributions to the activation and progression of immune responses. However, many of the features that make these two cell types unique are not opposing, but instead complementary. This review will present cell-cell communication in this context and discuss how complementarity makes fibroblasts and macrophages highly compatible partners in the maintenance of tissue homeostasis.
成纤维细胞和巨噬细胞是所有哺乳动物组织中普遍存在的细胞类型。这些细胞在许多方面存在差异，包括它们的细胞起源、在组织内更新、募集和迁移的动态、在组织结构和信号分子分泌中的作用以及对免疫反应的激活和进展的贡献。然而，使这两种细胞类型具有独特性的许多特征并不是相互对立的，而是互补的。本综述将在这一背景下介绍细胞间通讯，并讨论这种互补性如何使成纤维细胞和巨噬细胞成为维持组织内稳态的高度兼容的伙伴。
