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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Akimoto Y, Uda A, Omata H, Nishimura H, Komiya M, Kaneko K, Fujii A, Tamura T

Second Department of Oral Surgery, Nihon University School of Dentistry, Chiba, Japan.

Gen Pharmacol. 1988;19(4):515-6. doi: 10.1016/0306-3623(88)90156-5.

Ampicillin concentrations in human serum and periodontal membrane after a single oral administration of talampicillin (500 mg) were assayed by the agar diffusion (paper disc) method. 2. The peak times of serum and periodontal membrane were identical, being 150 min after administration. 3. The peak concentrations of serum and periodontal membrane were 7.81 micrograms/ml and 4.11 micrograms/g, respectively. 4. The mean ratio of periodontal membrane to serum concentration at the peak time was 0.53.

采用琼脂扩散（纸片）法测定单次口服酞氨苄青霉素（500毫克）后人血清和牙周膜中的氨苄青霉素浓度。2. 血清和牙周膜的峰值时间相同，给药后150分钟出现峰值。3. 血清和牙周膜的峰值浓度分别为7.81微克/毫升和4.11微克/克。4. 峰值时间时牙周膜与血清浓度的平均比值为0.53。

Akimoto Y, Uda A, Omata H, Nishimura H, Komiya M, Kaneko K, Fujii A, Tamura T

Second Department of Oral Surgery, Nihon University School of Dentistry, Chiba, Japan.

Gen Pharmacol. 1988;19(4):515-6. doi: 10.1016/0306-3623(88)90156-5.

Ampicillin concentrations in human serum and periodontal membrane after a single oral administration of talampicillin (500 mg) were assayed by the agar diffusion (paper disc) method. 2. The peak times of serum and periodontal membrane were identical, being 150 min after administration. 3. The peak concentrations of serum and periodontal membrane were 7.81 micrograms/ml and 4.11 micrograms/g, respectively. 4. The mean ratio of periodontal membrane to serum concentration at the peak time was 0.53.

采用琼脂扩散（纸片）法测定单次口服酞氨苄青霉素（500毫克）后人血清和牙周膜中的氨苄青霉素浓度。2. 血清和牙周膜的峰值时间相同，给药后150分钟出现峰值。3. 血清和牙周膜的峰值浓度分别为7.81微克/毫升和4.11微克/克。4. 峰值时间时牙周膜与血清浓度的平均比值为0.53。