单次口服巴氨西林后人体血清和牙周膜中的氨苄西林浓度。

Ampicillin concentrations in human serum and periodontal membrane following a single oral administration of bacampicillin.

作者信息

Akimoto Y, Shibutani J, Nishimura H, Komiya M, Shibata T, Tadokoro H, Kaneko K, Fujii A, Tamura T

出版信息

Gen Pharmacol. 1986;17(2):227-9. doi: 10.1016/0306-3623(86)90143-6.

Abstract

Ampicillin concentrations in human serum and periodontal membrane after a single oral administration of bacampicillin (500 mg) were assayed by the agar diffusion (paper disc) method. The peak times of serum and periodontal membrane were nearly identical, being approx. 90 min after administration. The peak concentrations of serum and periodontal membrane were 12.81 micrograms/ml and 6.97 micrograms/g, respectively. The concentration ratio of periodontal membrane to serum at the peak time was 0.56.

摘要

采用琼脂扩散（纸片）法测定单次口服巴氨西林（500毫克）后人体血清和牙周膜中的氨苄西林浓度。血清和牙周膜的峰值时间几乎相同，给药后约90分钟出现峰值。血清和牙周膜的峰值浓度分别为12.81微克/毫升和6.97微克/克。峰值时间牙周膜与血清的浓度比为0.56。