Akimoto Y, Kaneko K, Fujii A, Tamura T
J Oral Maxillofac Surg. 1985 Apr;43(4):270-6. doi: 10.1016/0278-2391(85)90286-1.
Eighty-one patients who underwent the extraction of impacted mandibular third molars in the nonfasting state were given a single oral dose of talampicillin (500 mg) preoperatively. Specimens of venous blood (n = 132), gingiva (n = 70), mandibular bone (n = 78), dental follicle (n = 63), and dental pulp (n = 59) were obtained during the operation and assayed for ampicillin content. The mean peak concentrations in serum (9.64 micrograms/ml), gingiva (4.72 micrograms/mg), mandibular bone (1.77 micrograms/ml), dental follicle (3.46 micrograms/ml), and dental pulp (5.53 micrograms/mg) all occurred at approximately 150 minutes after administration of talampicillin. The ratios of the corresponding serum concentration to the peak concentrations in the various oral tissues when both were plotted as drug concentration curves were: gingiva, 0.50; mandibular bone, 0.16; dental follicle, 0.34; and dental pulp, 0.52. Talampicillin was absorbed well by the intestine, and sufficient concentrations of the resulting metabolite, ampicillin, were found in oral tissues.
81例在非禁食状态下接受下颌阻生第三磨牙拔除术的患者，术前口服单剂量的替卡西林（500毫克）。术中采集静脉血样本（n = 132）、牙龈样本（n = 70）、下颌骨样本（n = 78）、牙囊样本（n = 63）和牙髓样本（n = 59），并检测其中氨苄西林的含量。替卡西林给药后约150分钟时，血清（9.64微克/毫升）、牙龈（4.72微克/毫克）、下颌骨（1.77微克/毫升）、牙囊（3.46微克/毫升）和牙髓（5.53微克/毫克）中的平均峰值浓度均出现。将血清浓度与各口腔组织中的峰值浓度以药物浓度曲线形式绘制时，相应的血清浓度与各口腔组织峰值浓度的比值分别为：牙龈，0.50；下颌骨，0.16；牙囊，0.34；牙髓，0.52。替卡西林在肠道吸收良好，且在口腔组织中发现了足够浓度的代谢产物氨苄西林。
