CRISPR-Cas9可导致染色体碎裂。 - Suppr

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CRISPR-Cas9 can cause chromothripsis.

作者信息

Urnov Fyodor D

机构信息

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, USA.

Innovative Genomics Institute, Berkeley, CA, USA.

出版信息

Nat Genet. 2021 Jun;53(6):768-769. doi: 10.1038/s41588-021-00881-4.

DOI:10.1038/s41588-021-00881-4

PMID:34103715

Abstract

摘要

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Nat Genet. 2021 Jun;53(6):768-769. doi: 10.1038/s41588-021-00881-4.

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Stem Cells Transl Med. 2022 Oct 21;11(10):1003-1009. doi: 10.1093/stcltm/szac064.

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Brief Funct Genomics. 2020 May 20;19(3):164-174. doi: 10.1093/bfgp/elz031.

CRISPR-Cas9 System: Opportunities and Concerns.

Clin Chem. 2016 Oct;62(10):1304-11. doi: 10.1373/clinchem.2016.263186. Epub 2016 Aug 22.

Assessing Off-Target Editing of CRISPR-Cas9 Systems.

CRISPR J. 2020 Dec;3(6):430-432. doi: 10.1089/crispr.2020.29116.smi.

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Cancer Lett. 2019 Apr 10;447:48-55. doi: 10.1016/j.canlet.2019.01.017. Epub 2019 Jan 23.

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Plant Cell Physiol. 2018 Aug 1;59(8):1608-1620. doi: 10.1093/pcp/pcy079.

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引用本文的文献

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本文引用的文献

Frequent loss of heterozygosity in CRISPR-Cas9-edited early human embryos.

Proc Natl Acad Sci U S A. 2021 Jun 1;118(22). doi: 10.1073/pnas.2004832117. Epub 2021 Apr 9.

Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing.

Nat Genet. 2021 Jun;53(6):895-905. doi: 10.1038/s41588-021-00838-7. Epub 2021 Apr 12.