Takase H, Miura O, Ito K
Nihon Yakurigaku Zasshi. 1987 May;89(5):299-306. doi: 10.1254/fpj.89.299.
We studied the effects of OGT, SST, AS and DST on ethanol- and aspirin-induced reduction of gastric transmucosal potential difference (PD) in rats as an index of gastric mucosal damage, and these effects were compared with those of sucralfate, 16,16-dimethyl-prostaglandin E2 (DMPGE2), cimetidine and proglumide. 1) OGT and SST as well as sucralfate and DMPGE2 significantly inhibited the PD reduction induced by ethanol and aspirin. 2) AS and DST as well as cimetidine significantly inhibited the PD reduction induced by aspirin, but not by ethanol. 3) Proglumide did not influence the PD reduction induced by ethanol and aspirin. 4) OGT alone, like sucralfate and proglumide, showed no influence on the basal PD, while SST, AS and DST, like DMPGE2 and cimetidine, increased the basal PD. These results suggest that OGT, SST, AS and DST protect the gastric mucosal barrier, and this effect of OGT differs from that of SST, AS and DST.
我们研究了燕麦β-葡聚糖（OGT）、生长抑素（SST）、铝硅酸镁（AS）和二硫苏糖醇（DST）对乙醇和阿司匹林诱导的大鼠胃黏膜跨膜电位差（PD）降低的影响，以此作为胃黏膜损伤的指标，并将这些影响与硫糖铝、16,16-二甲基前列腺素E2（DMPGE2）、西咪替丁和丙谷胺的影响进行比较。1）OGT和SST以及硫糖铝和DMPGE2显著抑制了乙醇和阿司匹林诱导的PD降低。2）AS和DST以及西咪替丁显著抑制了阿司匹林诱导的PD降低，但对乙醇诱导的PD降低无抑制作用。3）丙谷胺对乙醇和阿司匹林诱导的PD降低无影响。4）单独使用OGT，与硫糖铝和丙谷胺一样，对基础PD无影响，而SST、AS和DST，与DMPGE2和西咪替丁一样，增加了基础PD。这些结果表明，OGT、SST、AS和DST可保护胃黏膜屏障，且OGT的这种作用与SST、AS和DST的作用不同。
