Mikhaleva Lyudmila M, Radzinsky Victor E, Orazov Mekan R, Khovanskaya Tatyana N, Sorokina Anastasia V, Mikhalev Sergey A, Volkova Snezhana V, Shustova Victoria B, Sinelnikov Mikhail Y
Laboratory of Clinical Morphology, Research Institute of Human Morphology, Moscow, Russia.
Peoples' Friendship University (RUDN), Moscow, Russia.
Int J Womens Health. 2021 Jun 1;13:525-537. doi: 10.2147/IJWH.S306135. eCollection 2021.
To review the mechanisms of endometriosis development, including those related to epigenetic mutations, cellular dysregulation, inflammatory processes, and oxidative stress.
A systematic literature review regarding current aspects of endometriosis etiology, genesis and development was performed using the PubMed, Google Scholar, and eLibrary databases. Keywords included endometriosis, etiology, development, genesis, associations and mechanisms. A multilingual search was performed.
Several mechanisms underline the pathophysiological pathways for endometriosis development. Epigenetic mutations, external and internal influences, and chronic conditions have a significant impact on endometriosis development, survival and regulation. Several historically valid theories on endometriosis development were discussed, as well as updated findings.
Despite recent advances, fundamental problems in understanding endometriosis remain unresolved. The identification of unknown circulating epithelial progenitors or stem cells that are responsible for epithelial growth in both the endometrium and endometriotic foci seems to be the next step in solving these questions.
综述子宫内膜异位症的发病机制，包括与表观遗传突变、细胞调节异常、炎症过程和氧化应激相关的机制。
使用PubMed、谷歌学术和电子图书馆数据库，对子宫内膜异位症病因、起源和发展的当前方面进行系统的文献综述。关键词包括子宫内膜异位症、病因、发展、起源、关联和机制。进行了多语言搜索。
几种机制构成了子宫内膜异位症发展的病理生理途径。表观遗传突变、外部和内部影响以及慢性疾病对子宫内膜异位症的发展、存活和调节有重大影响。讨论了几种关于子宫内膜异位症发展的历史上有效的理论以及最新发现。
尽管最近取得了进展，但在理解子宫内膜异位症方面的基本问题仍未解决。识别负责子宫内膜和子宫内膜异位症病灶上皮生长的未知循环上皮祖细胞或干细胞似乎是解决这些问题的下一步。
