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表现为腭部肿胀的成人横纹肌肉瘤罕见变异型

Rare Variant of Adult Rhabdomyosarcoma Presenting as a Palatal Swelling.

作者信息

Iqbal Hafiz Aamer, Anjum Rabia, Naseem Nadia

机构信息

Dr. Hafiz Aamer Iqbal, BDS; FCPS (Oral and Maxillofacial Surgery) Department of Oral & Maxillofacial, Surgery Services Hospital, Lahore, Pakistan.

Dr. Rabia Anjum, BDS; MPhil (Oral Pathology) Assistant Professor, Department of Oral Pathology, University of Health Sciences, Lahore, Pakistan.

出版信息

Pak J Med Sci. 2021 May-Jun;37(3):922-925. doi: 10.12669/pjms.37.3.3305.

DOI:10.12669/pjms.37.3.3305
PMID:34104191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8155427/
Abstract

A 26-year-old male was referred to the Department of Oral and Maxillofacial Surgery of a tertiary care hospital in Lahore with chief complaint of painless swelling on the right palate of 40 days duration. Clinical differential diagnosis included squamous cell carcinoma, Ewing sarcoma, fibrosarcoma, neuroblastoma and rhabdomyosarcoma. Computed tomography scan revealed hypodense mass with necrotic changes. Histological examination of the excised tumor revealed malignant neoplasm arranged in fascicles and bundles comprising of spindle cells with pleomorphic, hyperchromatic nuclei and increased atypical mitosis. Immunohistochemical analysis showed negative staining with Cytokeratin, S100, CD34, Stat6, h-Caldesmon and EMA while the tumour cells were positive for desmin, myogenin, smooth muscle actin, CD-99 and MyoD1 thus confirming the diagnosis of spindle cell rhabdomyosarcoma.

摘要

一名26岁男性因右侧上腭无痛性肿胀40天被转诊至拉合尔一家三级护理医院的口腔颌面外科。临床鉴别诊断包括鳞状细胞癌、尤因肉瘤、纤维肉瘤、神经母细胞瘤和横纹肌肉瘤。计算机断层扫描显示低密度肿块伴有坏死改变。切除肿瘤的组织学检查显示恶性肿瘤呈束状和条索状排列，由具有多形性、核深染和非典型有丝分裂增加的梭形细胞组成。免疫组织化学分析显示细胞角蛋白、S100、CD34、信号转导和转录激活因子6、h-钙调蛋白和上皮膜抗原染色均为阴性，而肿瘤细胞结蛋白、肌细胞生成素、平滑肌肌动蛋白、CD-99和肌分化抗原1呈阳性，从而确诊为梭形细胞横纹肌肉瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/8155427/669ac810bafa/PJMS-37-922-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/8155427/3cf37f33e30f/PJMS-37-922-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/8155427/24515046eb47/PJMS-37-922-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/8155427/a230a6b2fb10/PJMS-37-922-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/8155427/669ac810bafa/PJMS-37-922-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/8155427/3cf37f33e30f/PJMS-37-922-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/8155427/24515046eb47/PJMS-37-922-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/8155427/a230a6b2fb10/PJMS-37-922-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b0/8155427/669ac810bafa/PJMS-37-922-g004.jpg

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Indian J Surg Oncol. 2020 Mar;11(1):127-130. doi: 10.1007/s13193-019-00991-w. Epub 2019 Nov 13.
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Primary duodenal embryonal rhabdomyosarcoma in adults: a case report.成人原发性十二指肠胚胎性横纹肌肉瘤：一例报告
AME Case Rep. 2019 Aug 6;3:29. doi: 10.21037/acr.2019.07.09. eCollection 2019.
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Oral rhabdomyosarcoma in an adult male: A rare case report.一名成年男性的口腔横纹肌肉瘤：一例罕见病例报告。
J Oral Maxillofac Pathol. 2018 May-Aug;22(2):285. doi: 10.4103/jomfp.JOMFP_11_17.
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Clinicopathologic features of 300 rhabdomyosarcomas with emphasis upon differential expression of skeletal muscle specific markers in the various subtypes: A single institutional experience.300例横纹肌肉瘤的临床病理特征，重点关注不同亚型中骨骼肌特异性标志物的差异表达：单中心经验
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Rhabdomyosarcoma, Spindle Cell/Sclerosing Variant: A Clinical and Histopathological Examination of this Rare Variant with Three New Cases from the Oral Cavity.横纹肌肉瘤，梭形细胞/硬化性变异型：对这一罕见变异型的临床和组织病理学检查并附3例口腔新病例
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