Jammes Y, Orehek J
Pathol Biol (Paris). 1977 Nov;25(9):599-604.
In 10 healthy conscious subjects we have studied the effect of a sustained bronchospasm induced by aerosol of carbachol on the pattern of breathing and the ventilatory response to lung inflation which reflects the Breuer Hering reflex. Bronchospasm was assessed by measuring airway resistance and functional residual capacity by plethysmography. After bronchospasm the ventilatory response to inflation was unchanged and the role played by afferents related to such a reflex in controlling pattern of breathing was preserved. Moreover the ration between the threshold volume of the reflex and tidal volume (VT) remained constant. These data suggest that this ration could represent a central set point for VT control. Variable changes in the ventilatory pattern were also observed and are discussed in relation to the previous data.
在10名健康清醒受试者中，我们研究了卡巴胆碱气雾剂诱发的持续性支气管痉挛对呼吸模式以及反映布雷尔-黑林反射的肺充气通气反应的影响。通过体积描记法测量气道阻力和功能残气量来评估支气管痉挛。支气管痉挛后，对充气的通气反应未改变，与该反射相关的传入神经在控制呼吸模式中所起的作用得以保留。此外，反射阈值容积与潮气量（VT）之间的比值保持恒定。这些数据表明，该比值可能代表VT控制的一个中枢设定点。还观察到通气模式的可变变化，并结合先前的数据进行了讨论。
