菜园工人外周血淋巴细胞染色体畸变及姐妹染色单体交换的检测

Screening of chromosomal aberrations and sister chromatid exchanges in peripheral lymphocytes of vegetable garden workers.

Rupa D S, Rita P, Reddy P P, Reddi O S

Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Andhra Pradesh, India.

Hum Toxicol. 1988 Jul;7(4):333-6. doi: 10.1177/096032718800700406.

Abstract

Twenty-five male workers occupationally exposed to DDT, BHC malathion, parathion, dimethoate, fenitrothion, urea and gromor were selected as subjects for the analysis of chromosomal aberrations and sister chromatid exchanges (SCE) in peripheral lymphocytes. 2. Blood samples were collected from 30 normal healthy males from the same age group and socioeconomic class for the control. 3. The frequency of chromosomal aberrations and SCEs increased significantly irrespective of the duration of exposure to pesticides, when compared to controls.

摘要

选取25名职业性接触滴滴涕、六六六、马拉硫磷、对硫磷、乐果、杀螟硫磷、尿素和谷乐生的男性工人作为研究对象，分析其外周血淋巴细胞的染色体畸变和姐妹染色单体交换（SCE）情况。2. 采集30名来自同一年龄组且社会经济阶层相同的正常健康男性的血样作为对照。3. 与对照组相比，无论接触农药的时间长短，染色体畸变和SCE的频率均显著增加。