Rupa D S, Reddy P P, Sreemannarayana K, Reddi O S
Environmental Toxicology Program, University of California, Riverside 92521.
Environ Mol Mutagen. 1991;18(2):136-8. doi: 10.1002/em.2850180209.
In the present study 61 male pesticide applicators who worked in cotton fields and regularly sprayed pesticides such as DDT, BHC, endosulfan, malathion, methyl parathion, phosphamidon, dimethoate, monocrotophos, quinalphos fenvelrate, and cypermethrin were analyzed for sister chromatid exchanges, mitotic index, and cell cycle kinetics in peripheral lymphocytes. Subjects who handled pesticides were non-smokers and teetotalers and the data were compared with the matched control group. Statistical analysis revealed that the frequency of sister chromatid exchanges was significantly higher among the pesticide applicators at all the durations of exposure when compared to controls. Subjects exposed to pesticides also showed cell cycle delay and decrease in mitotic index when compared to the control group.
在本研究中，对61名在棉田工作且经常喷洒滴滴涕、六六六、硫丹、马拉硫磷、甲基对硫磷、磷胺、乐果、久效磷、喹硫磷、杀灭菊酯和氯氰菊酯等农药的男性施药者的外周血淋巴细胞进行了姐妹染色单体交换、有丝分裂指数和细胞周期动力学分析。接触农药的受试者不吸烟且不饮酒，数据与匹配的对照组进行了比较。统计分析表明，与对照组相比，在所有暴露时间段内，农药施药者的姐妹染色单体交换频率均显著更高。与对照组相比，接触农药的受试者还表现出细胞周期延迟和有丝分裂指数降低。
