Kersin Sinem Gülcan, Özek Eren
Division of Neonatology, Department of Pediatrics, Marmara University School of Medicine, İstanbul, Turkey.
Turk Arch Pediatr. 2021 May 1;56(3):187-191. doi: 10.5152/TurkArchPediatr.2021.21006. eCollection 2021.
Each mammal produces milk specific to its newborn that meets all nutritional needs. Breast milk is not only a secretory product but is also a complex liquid containing several components that provide enteral nutrition. The stage of lactation, the fullness of the breast, the feeding of the baby, and the health of the mother during the breastfeeding period cause differences in the composition of breast milk. Although the positive effects of breast milk on the physical and intellectual development of a child in the short and long term have been known for centuries, its mechanism has not been elucidated. Stem cells are defined as the cells that possess specific markers and have not undergone differentiation. Under suitable conditions and stimuli, they can differentiate into desired cells. The detection of stem cells, whose exact origin is not known, in breast milk and their demonstration in the baby's body have prompted the necessity of exploring the possible role of stem cells in the treatment of diseases. In this review, breast milk-derived stem cells and their possible role in neonatology are discussed.
每种哺乳动物都会分泌适合其新生幼崽的乳汁，以满足其所有营养需求。母乳不仅是一种分泌产物，也是一种含有多种成分的复杂液体，可提供肠内营养。哺乳期阶段、乳房充盈度、婴儿喂养情况以及母乳喂养期间母亲的健康状况都会导致母乳成分存在差异。尽管几个世纪以来人们都知道母乳对儿童短期和长期的身体及智力发育具有积极作用，但其作用机制尚未阐明。干细胞被定义为具有特定标志物且尚未分化的细胞。在合适的条件和刺激下，它们可以分化为所需的细胞。在母乳中检测到确切来源不明的干细胞，并在婴儿体内证实了这些干细胞的存在，这促使人们有必要探索干细胞在疾病治疗中的可能作用。在这篇综述中，将讨论母乳来源的干细胞及其在新生儿学中的可能作用。
