Bartle W R, Walker S E, Silverberg J D
Department of Pharmacy, Sunnybrook Medical Centre, University of Toronto, North York, Ontario, Canada.
Int J Clin Pharmacol Ther Toxicol. 1988 Jun;26(6):285-7.
The rectal absorption of propylthiouracil (PTU) was studied and compared to oral absorption in normal volunteers. Plasma levels of PTU after administration of suppositories of PTU base and PTU diethanolamine were significantly lower compared to the oral route. Elevated plasma reverse T3 levels were demonstrated after each treatment, however, suggesting a desirable therapeutic effect at this dosage level for all preparations.
研究了丙硫氧嘧啶（PTU）的直肠吸收情况，并与正常志愿者的口服吸收进行了比较。与口服途径相比，给予PTU碱基栓剂和PTU二乙醇胺后，PTU的血浆水平显著降低。然而，每次治疗后血浆反式T3水平均升高，表明所有制剂在该剂量水平下均具有理想的治疗效果。
