Music and Health Sciences Research Collaboratory, Faculty of Music, University of Toronto, Toronto, Canada.
Faculty of Kinesiology, University of Toronto, Toronto, Canada.
PLoS One. 2021 Jun 9;16(6):e0245107. doi: 10.1371/journal.pone.0245107. eCollection 2021.
The study compared the prevalence of the Val66Met Brain-derived Neurotrophic Factor single nucleotide polymorphism (rs6265) in a sample of musicians (N = 50) to an ethnically matched general population sample from the 1000 Human Genome Project (N = 424). Met-carriers of the polymorphism (Val/Met and Met/Met genotypes) are typically present in 25-30% of the general population and have associated deficits in motor learning and plasticity. Many studies have assessed the benefits of long-term music training for neuroplasticity and motor learning. This study takes a unique genetic approach investigating if the prevalence of the Val66Met BDNF polymorphism, which negatively affects motor learning, is significantly different in musicians from the general population. Our genotype and allele frequency analyses revealed that the distribution of the Val66Met polymorphism was not significantly different in musicians versus the general population (p = 0.6447 for genotype analysis and p = 0.8513 allele analysis). In the Musician sample (N = 50), the prevalence of the Val/Met genotype was 40% and the prevalence of the Met/Met genotype was 2%. In the 1000 Human Genome Project subset (N = 424), the prevalence of Val/Met was 33.25% and the Met/Met genotype prevalence was 4%. Therefore, musicians do exist with the Val66Met polymorphism and the characteristics of long-term music training may compensate for genetic predisposition to motor learning deficits. Since the polymorphism has significant implications for stroke rehabilitation, future studies may consider the implications of the polymorphism in music-based interventions such as Neurologic Music Therapy.
该研究比较了音乐演奏者样本（N=50）中 Val66Met 脑源性神经营养因子单核苷酸多态性（rs6265）的患病率与 1000 人类基因组计划中来自种族匹配的一般人群样本（N=424）。该多态性的 Met 携带者（Val/Met 和 Met/Met 基因型）通常存在于 25-30%的一般人群中，并且与运动学习和可塑性的缺陷相关。许多研究评估了长期音乐训练对神经可塑性和运动学习的益处。本研究采用独特的遗传方法，研究了对运动学习有负面影响的 Val66Met BDNF 多态性的患病率是否在音乐演奏者与一般人群之间存在显著差异。我们的基因型和等位基因频率分析表明，Val66Met 多态性的分布在音乐演奏者与一般人群之间没有显著差异（基因型分析的 p=0.6447，等位基因分析的 p=0.8513）。在音乐演奏者样本（N=50）中，Val/Met 基因型的患病率为 40%，Met/Met 基因型的患病率为 2%。在 1000 人类基因组计划子集中（N=424），Val/Met 的患病率为 33.25%，Met/Met 基因型的患病率为 4%。因此，确实存在携带 Val66Met 多态性的音乐演奏者，而长期音乐训练的特点可能会弥补运动学习缺陷的遗传倾向。由于该多态性对中风康复具有重要意义，未来的研究可能会考虑该多态性在基于音乐的干预措施（如神经音乐疗法）中的影响。
