Department of Endocrinology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
Department of Cardiology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
Phytother Res. 2021 Oct;35(10):5477-5486. doi: 10.1002/ptr.7182. Epub 2021 Jun 9.
The antioxidant and antiinflammatory properties of purslane (Portulaca oleracea L.) are known in preclinical studies but further examination is needed to expand their potential into the clinical scenario. A systematic review and meta-analysis of randomized controlled trials were performed to elucidate the effects of purslane supplementation on C-reactive protein (CRP) levels and biomarkers of oxidative stress in metabolic syndrome, its related complications, and other diseases. PubMed/MEDLINE, Web of Science, SCOPUS, and Embase were the databases searched. Heterogeneity was examined using the I-squared (I ) statistic, in which the source of heterogeneity was determined if the I -value was >50%. After all the screening processes, 10 studies met the eligibility criteria and were analyzed. Following purslane supplementation, CRP levels decreased significantly (weighted mean difference [WMD]: -0.33 mg/dl, 95% confidence interval [CI]: -0.66, -0.004, p = .047) but with significant heterogeneity (I = 87.4%, p = .001). Purslane supplementation did not significantly change serum levels of malondialdehyde (MDA) (WMD: -0.353 μm/L; 95% CI: -0.920, 0.213; I = 50.7%), total antioxidant capacity (TAC) (WMD: 0.090 mm/L, 95% CI: -0.081, 0.262; I = 47.1%), and superoxide dismutase (SOD) (WMD: 6.54 U/ml, 95% CI: -22.150, 35.236; I = 70.7%). Thus, this meta-analysis showed a positive effect of purslane supplementation as a tool to decrease CRP levels, but not to MDA, TAC, and SOD levels.
马齿苋（Portulaca oleracea L.）的抗氧化和抗炎特性在临床前研究中已有报道，但需要进一步研究将其潜在作用扩展到临床环境中。本系统评价和荟萃分析对随机对照试验进行了评估，以阐明马齿苋补充剂对代谢综合征及其相关并发症和其他疾病中 C 反应蛋白（CRP）水平和氧化应激生物标志物的影响。检索了 PubMed/MEDLINE、Web of Science、SCOPUS 和 Embase 数据库。使用 I 平方（I ）统计量检查异质性，如果 I 值>50%，则确定异质性的来源。经过所有筛选过程，有 10 项研究符合入选标准并进行了分析。在接受马齿苋补充剂后，CRP 水平显著下降（加权均数差 [WMD]：-0.33mg/dl，95%置信区间 [CI]：-0.66，-0.004，p=0.047），但存在显著异质性（I =87.4%，p=0.001）。马齿苋补充剂对血清丙二醛（MDA）水平（WMD：-0.353μm/L；95%CI：-0.920，0.213；I =50.7%）、总抗氧化能力（TAC）（WMD：0.090mm/L，95%CI：-0.081，0.262；I =47.1%）和超氧化物歧化酶（SOD）（WMD：6.54U/ml，95%CI：-22.150，35.236；I =70.7%）水平没有显著影响。因此，本荟萃分析表明，马齿苋补充剂作为降低 CRP 水平的工具具有积极作用，但对 MDA、TAC 和 SOD 水平没有影响。
