Student Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences, Tehran, Iran.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
J Food Biochem. 2021 Apr;45(4):e13625. doi: 10.1111/jfbc.13625. Epub 2021 Feb 9.
Inflammation and oxidative stress are involved in the pathogenesis of a myriad of chronic disorders. This systematic review and meta-analysis was designed to determine the effects of Nigella Sativa (NS) seed and seed oil consumption on several biomarkers of inflammation and oxidative stress. The Scopus, Web of Science, and PubMed-MEDLINE databases were systematically searched until August 2019. The quality assessment and heterogeneity of the selected randomized clinical trials (RCTs) were measured using the Jadad checklist, and Q and I tests, respectively. Finally, a total of 10 clinical RCTs were found to be eligible for this meta-analysis. The pooled findings showed that NS consumption significantly reduced serum high-sensitivity C-reactive protein (hs-CRP; WMD: -0.67, 95% CI: -1.29, -0.05, I = 95.7%), tumor necrosis factor-alpha (TNF-α; WMD: -2.29, 95% CI: -4.48, -0.11, I = 93%), and malondialdehyde (MDA; WMD: -1.18, 95% CI: -2.24, -0.12, I = 85.4%), and significantly increased total antioxidant capacity (TAC; WMD: 0.35, 95% CI: 0.10, 0.59, I = 77.1%), and superoxide dismutase (SOD; WMD: 66.30, 95% CI: 1.03, 131.57, I = 99.4%) levels. Overall, the results of this systematic review and meta-analysis imply that NS consumption may decrease inflammatory response and oxidative stress markers. PRACTICAL APPLICATIONS: Overall, the evidence supports the consumption of NS to reduce hs-CRP, TNF-α, and MDA, and to increase SOD and TAC levels. In addition, the subgroup analyses findings concluded that lower dosages of NS, longer durations of the intervention, and the use of NS seed oil may result in more effective action on inflammatory markers, but because of the limited number of trials, the results must be analyzed with caution, especially for the subgroup analysis. However, further prospective studies regarding the effect of NS consumption on biomarkers of inflammation and oxidative stress, with larger sample sizes, from various countries and longer follow-up periods, are required to confirm whether NS possesses veritable anti-inflammatory and antioxidant effects.
炎症和氧化应激与许多慢性疾病的发病机制有关。本系统评价和荟萃分析旨在确定黑种草（NS）种子和籽油的摄入对几种炎症和氧化应激生物标志物的影响。系统地检索了 Scopus、Web of Science 和 PubMed-MEDLINE 数据库，直至 2019 年 8 月。使用 Jadad 清单和 Q 和 I 检验分别评估纳入的随机临床试验（RCT）的质量评估和异质性。最后，共发现 10 项符合条件的临床 RCT 适合进行荟萃分析。汇总结果表明，NS 摄入可显著降低血清高敏 C 反应蛋白（hs-CRP；WMD：-0.67，95%CI：-1.29，-0.05，I = 95.7%）、肿瘤坏死因子-α（TNF-α；WMD：-2.29，95%CI：-4.48，-0.11，I = 93%）和丙二醛（MDA；WMD：-1.18，95%CI：-2.24，-0.12，I = 85.4%），并显著增加总抗氧化能力（TAC；WMD：0.35，95%CI：0.10，0.59，I = 77.1%）和超氧化物歧化酶（SOD；WMD：66.30，95%CI：1.03，131.57，I = 99.4%）水平。总体而言，本系统评价和荟萃分析的结果表明，NS 摄入可能会降低炎症反应和氧化应激标志物。实际应用：总的来说，证据支持 NS 的摄入可以降低 hs-CRP、TNF-α 和 MDA，增加 SOD 和 TAC 水平。此外，亚组分析结果表明，NS 的较低剂量、较长的干预时间以及 NS 籽油的使用可能会对炎症标志物产生更有效的作用，但由于试验数量有限，结果必须谨慎分析，尤其是对于亚组分析。然而，需要进行更多来自不同国家、具有更大样本量和更长随访期的关于 NS 消耗对炎症和氧化应激生物标志物影响的前瞻性研究，以确认 NS 是否具有真正的抗炎和抗氧化作用。
