Bas C, Bartolomé J, La Banda F, Porres J C, Quiroga J A, Mora I, Carreño V
Department of Gastroenterology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
J Hepatol. 1988 Apr;6(2):208-13. doi: 10.1016/s0168-8278(88)80033-3.
In order to document the incidence of hepatitis delta virus (HDV) replication markers and their relationship to HBV replication, 91 HBsAg chronic carriers were studied. Of these, 51 were anti-HD-positive (19 HBeAg-positive and 32 anti-HBe-positive). Liver HDAg was found in 75% of anti-HD-positive patients. Of the 19 patients who had anti-HD and HBeAg, 13 were HBV-DNA-positive. None of the anti-HBe patients were HBV-DNA-positive. No differences with respect to HBV-DNA concentration were observed between anti-HD-positive and -negative patients. Liver HDAg was detected with similar frequency in patients who were HBeAg- and HBV-DNA-positive (63.6%) and in those who were anti-HBe-positive (78.5%), with no statistically significant difference. HBcAg and HDAg were simultaneously detected in 36% of the anti-HD cases. Patients with anti-HD and HBV-DNA had the highest levels of transaminases (SGPT). Our results suggest that in certain patients HDV and HBV replication coexists without mutual inhibition.
为了记录丁型肝炎病毒（HDV）复制标志物的发生率及其与HBV复制的关系，对91例HBsAg慢性携带者进行了研究。其中，51例抗HD阳性（19例HBeAg阳性，32例抗HBe阳性）。75%的抗HD阳性患者肝脏中检测到HDAg。在19例抗HD和HBeAg阳性的患者中，13例HBV-DNA阳性。抗HBe患者均未检测到HBV-DNA阳性。抗HD阳性和阴性患者之间未观察到HBV-DNA浓度的差异。HBeAg和HBV-DNA阳性患者（63.6%）和抗HBe阳性患者（78.5%）肝脏中检测到HDAg的频率相似，无统计学显著差异。36%的抗HD病例同时检测到HBcAg和HDAg。抗HD和HBV-DNA阳性的患者转氨酶（SGPT）水平最高。我们的结果表明，在某些患者中HDV和HBV复制共存且无相互抑制。
