Post-Graduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Pharmacy Department, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
PLoS One. 2021 Jun 10;16(6):e0252785. doi: 10.1371/journal.pone.0252785. eCollection 2021.
To characterize the usage profile and the factors associated with the prolonged use of proton pump inhibitor drugs in a community pharmacy.
This is a cross-sectional, prospective and observational study involving interviews with 410 patients who acquired PPI for their own use from community pharmacies. To characterize the factors associated with the prolonged use of PPI, a multivariate logistic regression model was used.
Pantoprazole (42.7%) and omeprazole (31%) were the most acquired PPIs, prescribed mainly by gastroenterologists (49.5%). They are used in the morning, especially for gastrointestinal symptoms, however, they had been consumed for more than 5 years in 30% of cases. The factors associated with prolonged use are old age (OR 1.03 CI95% 1.01-1.05), body mass index (OR 1.07 CI95% 1.01-1.12), use of non-steroidal anti-inflammatories (OR 3.18 CI95% 1.20-8.43) and selective serotonin reuptake inhibitors (OR 3.5 95% CI 1.39-8.88).
PPIs are adequate in terms of indication and form of use, however, prolonged use associated with old age, being overweight and use of anti-inflammatories and antidepressants is frequent.
描述社区药店中质子泵抑制剂（PPI）药物长期使用的使用情况和相关因素。
这是一项横断面、前瞻性和观察性研究，涉及对 410 名从社区药店自行购买 PPI 的患者进行访谈。为了描述与 PPI 长期使用相关的因素，使用了多变量逻辑回归模型。
泮托拉唑（42.7%）和奥美拉唑（31%）是最常被获取的 PPI，主要由胃肠病学家开具（49.5%）。它们在早上使用，特别是用于胃肠道症状，但在 30%的情况下已经使用了超过 5 年。与长期使用相关的因素是年龄较大（OR 1.03 CI95% 1.01-1.05）、体重指数（OR 1.07 CI95% 1.01-1.12）、使用非甾体抗炎药（OR 3.18 CI95% 1.20-8.43）和选择性 5-羟色胺再摄取抑制剂（OR 3.5 95% CI 1.39-8.88）。
PPI 在适应证和使用方式方面是适当的，但是与年龄较大、超重以及使用抗炎药和抗抑郁药相关的长期使用是常见的。
